Endothelial-Derived miR-17∼92 Promotes Angiogenesis to Protect against Renal Ischemia-Reperfusion Injury.

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Abstract

Damage to the renal microvasculature is a hallmark of renal ischemia-reperfusion injury (IRI)-mediated AKI. The miR-17∼92 miRNA cluster (encoding miR-17, -18a, -19a, -20a, -19b-1, and -92a-1) regulates angiogenesis in multiple settings, but no definitive role in renal endothelium during AKI pathogenesis has been established.

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Author and article information

Journal

Journal ID (iso-abbrev): J Am Soc Nephrol

Title: Journal of the American Society of Nephrology : JASN

Publisher: American Society of Nephrology (ASN)

ISSN (Electronic): 1533-3450

ISSN (Print): 1046-6673

Publication date (Electronic): March 2021

Volume: 32

Issue: 3

Affiliations

[1 ] Division of Nephrology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

[2 ] Heart, Lung, Blood and Vascular Medicine Institute, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania Jacqueline.ho2@chp.edu simslucass@upmc.edu.

[3 ] Heart, Lung, Blood and Vascular Medicine Institute, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

[4 ] Department of Developmental Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

[5 ] Division of Nephrology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania Jacqueline.ho2@chp.edu simslucass@upmc.edu.

Article

Publisher Item ID: ASN.2020050717

DOI: 10.1681/ASN.2020050717

PMC ID: 7920169

PubMed ID: 33514560

SO-VID: 495f0077-0bf2-4b8a-8c3b-5ebdda382013

History

Keywords: microRNA,renal microvasculature,acute kidney injury

Data availability:

Keywords: microRNA, renal microvasculature, acute kidney injury

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