SYVN1 attenuates ferroptosis and alleviates spinal cord ischemia-reperfusion injury in rats by regulating the HMGB1/NRF2/HO-1 axis.

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Abstract

The ferroptosis of neurons is an important pathological mechanism of spinal cord ischemia reperfusion injury (SCIRI). Previous studies showed that synoviolin 1 (SYVN1) is a good prognostic marker of neurodegenerative diseases, but its mechanism is still unclear. This study aims to explore the role of SYVN1 in the ferroptosis of neurons and to clarify its internal mechanism.

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Journal

Journal ID (iso-abbrev): Int Immunopharmacol

Title: International immunopharmacology

Publisher: Elsevier BV

ISSN (Electronic): 1878-1705

ISSN (Print): 1567-5769

Publication date (Electronic): Oct 2023

Volume: 123

Affiliations

[1 ] Department of Anesthesiology, The First Hospital of China Medical University, Shenyang 110001, Liaoning Province, China.

[2 ] Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China. Electronic address: dingsheng_liu@163.com.

Article

Publisher Item ID: S1567-5769(23)01127-X

DOI: 10.1016/j.intimp.2023.110802

PubMed ID: 37591122

SO-VID: 4936fd0b-bd4d-4873-a39a-6ebfa89dab42

History

Keywords: SCIRI,HMGB1,Primary spinal cord neurons,The NRF2/HO-1 pathway,SYVN1

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Keywords: SCIRI, HMGB1, Primary spinal cord neurons, The NRF2/HO-1 pathway, SYVN1

SYVN1 attenuates ferroptosis and alleviates spinal cord ischemia-reperfusion injury in rats by regulating the HMGB1/NRF2/HO-1 axis.

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