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Finding the perfect spot for fluorine: Improving potency up to 40-fold during a rational fluorine scan of a Bruton’s Tyrosine Kinase (BTK) inhibitor scaffold
Yan Lou ,
Zachary K. Sweeney ,
Andreas Kuglstatter ,
Dana Davis ,
David M. Goldstein ,
Xiaochun Han ,
Junbae Hong ,
Buelent Kocer ,
Rama K. Kondru ,
Renee Litman ,
Joel McIntosh ,
Keshab Sarma ,
Judy Suh ,
Joshua Taygerly ,
Timothy D. Owens
January 2015
January 2015
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