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Inhibition of green tea catechins against the growth of cancerous human colon and hepatic epithelial cells
Shinichi Uesato ,
Yutaka Kitagawa ,
Masaaki Kamishimoto ,
Ayako Kumagai ,
Hitoshi Hori ,
Hideko Nagasawa
September 2001
September 2001
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Abstract
The ability of (-)-epicatechin (EC), (-)-epigallocatechin (EGC) and (-)-epigallocatechin
gallate (EGCG) to inhibit the growth of HCT 116 colorectal and Hep G2 hepatocellular
carcinoma cells was examined by MTT and clonogenic assays (CA). The respective catechins
inhibited the growth of HCT 116 more strongly than Hep G2. In MTT assay, IC(50) values
of EGC and EGCG against HCT 116 grew smaller on prolongation of the exposure times
of the cells to the catechins. In CA, however, these two catechins had IC(50) values
ranging between 7.6+/-0.4 and 11.2+/-0.5 microM against the same cells regardless
of the exposure times. EC showed much weaker growth inhibitions relative to the two
aforementioned catechins.
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