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      Unusual presentation of metastatic carcinoma cervix with clinically silent primary identified by 18F-flouro deoxy glucose positron emission tomography/computed tomography

      case-report

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          Abstract

          Carcinoma cervix is the most common gynecological malignancy among Indian women. The common symptoms at presentation include abnormal vaginal bleeding, unusual discharge from the vagina, or pain during coitus and postmenopausal bleeding. Rarely, few patients may present with distant metastases without local symptoms. We present two patients with an unusual presentation of metastatic disease without any gynecological symptoms, where 18F-flouro deoxy glucose positron emission tomography/computed tomography helped in identifying the primary malignancy in the uterine cervix.

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          The present scenario of cervical cancer control and HPV epidemiology in India: an outline.

          J Giftson Senapathy, P. Umadevi, P Kannika (2011)
          To give a clear picture with epidemiological evidence about the present scenario of cervical cancer control and HPV in India. Review of published studies, concentrating on recent systematic reviews, meta-analyses and large prospective studies. Cervical cancer is unique among cancers in that it can largely be prevented through screening and removal of precursor lesions. It is the second most common cancer among women worldwide and is the most common malignancy in developing countries, particularly in India. Nowadays, cervical screening for women is necessary because there are no signs and symptoms of cervical precancers. The establishment of a prevention program is urgently required considering both screening and vaccination. But most women in India do not have access to effective screening programmes. It has been estimated that in India, even with a major effort to expand cytology services, it will not be possible to screen even one-fourth of the population once in a lifetime in the near future. New HPV vaccines will also help prevent HPV infection and the precancerous changes that lead to cervical cancer. The focus on detection and prevention of cervical cancer must be emphasized in a highly populated country like India to prevent its extensive spread.
          Article 0 comments Cited 19 times – based on 0 reviews     Review now
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            Bone metastasis from cervical cancer.

            K Ahmad, Kevin Powers, Byeal-I Han … (1994)
            This retrospective analysis examines the frequency, distribution, and the pattern of disease progression of bone metastasis in patients treated for cervical cancer and the use and results of palliative intent radiation therapy. Charts, films, and other available records were reviewed for the 41 patients with bone metastasis of the 496 patients with invasive cervical cancer treated at the Gershenson Radiation Oncology Center, Detroit, Michigan, from 1980 through 1989. Several patterns of bone metastasis were observed: (1) direct extension into bone from the parametrial extensions of the primary or recurrent pelvic tumor, (2) direct extension into bone from parenchymal metastasis to distant lymph nodes or lung, (3) regional hematogenous metastasis compatible with Batson's venous plexus distribution, and (4) systemic hematogenous metastasis to distant bones. Eighty percent of the patients were irradiated, and of those, 70% experienced pain relief. Bone metastasis in patients with cervical cancer is an infrequent but significant occurrence with associated severe dysfunction, other signs of local and distant failure, and short life expectancy. Radiation therapy provides moderate palliation for treatable patients.
            Article 0 comments Cited 16 times – based on 0 reviews     Review now
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              Carcinoma of uterine cervix with isolated metastasis to fibula and its unusual behavior: report of a case and review of literature.

              Rajesh Pasricha, Anu Tiwari, Tanu Aggarwal … (2015)
              Bone metastasis from carcinoma cervix is uncommon, especially in the distal appendicular skeleton. A 36 year old lady presented with carcinoma of uterine cervix, FIGO, stage IIb. She was treated with radical radiotherapy. Nine months later, she developed an isolated lytic lesion in right fibula, which turned out to be a metastatic lesion. The patient is doing well, 3 years after the surgical excision of metastasis. This is one of the few documented cases of metastasis to fibula, arising from carcinoma of uterine cervix and probably the first with isolated metastasis of this site. Unlike the dismal outcome commonly seen in patients with bone secondaries, she continues to be disease free and alive at 39 months of follow up, after the development of skeletal metastasis.
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                Author and article information

                Journal
                Journal ID (nlm-ta): Indian J Nucl Med
                Journal ID (iso-abbrev): Indian J Nucl Med
                Journal ID (publisher-id): IJNM
                Title: Indian Journal of Nuclear Medicine : IJNM : The Official Journal of the Society of Nuclear Medicine, India
                Publisher: Medknow Publications & Media Pvt Ltd (India )
                ISSN (Print): 0972-3919
                ISSN (Electronic): 0974-0244
                Publication date (Print): Apr-Jun 2016
                Volume: 31
                Issue: 2
                Pages: 134-137
                Affiliations
                [1]Department of Nuclear Medicine, Global Hospitals, Vadapalani, India
                [1 ]Department of Medical Oncology, SIMS Hospital, Vadapalani, India
                [2 ]Department of Radiology, Global Hospitals, Vadapalani, India
                [3 ]Department of Histopathology, Global Health City, Chennai, Tamil Nadu, India
                Author notes
                Address for correspondence: Dr. Raja Senthil, Department of Nuclear Medicine, Global Hospitals, No. 439, Perumbakkam, Chennai - 600 100, Tamil Nadu, India. E-mail: senthilrajapgi@ 123456yahoo.com
                Article
                Publisher ID: IJNM-31-134
                DOI: 10.4103/0972-3919.178267
                PMC ID: 4815387
                PubMed ID: 27095863
                SO-VID: 48c34e12-3779-4bc6-8958-091164ee377e
                Copyright © Copyright: © Indian Journal of Nuclear Medicine
                License:

                This is an open access article distributed under the terms of the Creative Commons Attribution NonCommercial ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non commercially, as long as the author is credited and the new creations are licensed under the identical terms.

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                Categories
                Subject: Case Report

                ScienceOpen disciplines: Radiology & Imaging
                Keywords: 18f-flouro deoxy glucose positron emission tomography/computed tomography,carcinoma cervix,unknown primary
                Data availability:
                ScienceOpen disciplines: Radiology & Imaging
                Keywords: 18f-flouro deoxy glucose positron emission tomography/computed tomography, carcinoma cervix, unknown primary

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