Busulfan plus cyclophosphamide versus busulfan plus fludarabine as a preparative regimen for allogeneic haemopoietic stem-cell transplantation in patients with acute myeloid leukaemia: an open-label, multicentre, randomised, phase 3 trial.

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Abstract

The standard busulfan-cyclophosphamide myeloablative conditioning regimen is associated with substantial non-relapse mortality in patients older than 40 years with acute myeloid leukaemia who are undergoing allogeneic stem-cell transplantation. Because the combination of busulfan plus fludarabine has been proposed to reduce non-relapse mortality, we aimed to compare this treatment with busulfan plus cyclophosphamide as a preparative regimen in these patients.

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Author and article information

Journal

Journal ID (iso-abbrev): Lancet Oncol.

Title: The Lancet. Oncology

ISSN (Electronic): 1474-5488

ISSN (Print): 1470-2045

Publication date (Electronic): Nov 2015

Volume: 16

Issue: 15

Affiliations

[1 ] Hematology and Bone Marrow Transplant Unit, Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy. Electronic address: arambaldi@hpg23.it.

[2 ] Hematology and Bone Marrow Transplant Unit, Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy.

[3 ] Fondazione Mario Negri Sud, Santa Maria Imbaro, Italy.

[4 ] Bone Marrow Transplant Unit, University of Torino, Turin, Italy.

[5 ] Hematology and Bone Marrow Transplant Unit, Ospedale Centrale di Bolzano, Bolzano, Italy.

[6 ] Bone Marrow Transplant Center, Ospedale Spirito Santo, Pescara, Italy.

[7 ] Hematology and Bone Marrow Transplant Unit, Ospedale San Bortolo, Vicenza, Italy.

[8 ] Hematology, Azienda Ospedali Riuniti, Ancona, Italy.

[9 ] Hematology and Bone Marrow Transplant Unit, Azienda Policlinico-Vittorio Emanuele, Catania, Italy.

[10 ] Unit of Hematology, Policlinico Universitario A Gemelli, Rome, Italy.

[11 ] Department of Emergency and Organ Transplantation, Section of Hematology with Transplantation, Medical School, University of Bari, Bari, Italy.

[12 ] Department of Hematology, Bone Marrow Transplant Unit, University of Firenze, Florence, Italy.

[13 ] Hematology and Bone Marrow Transplant Unit, Azienda Ospedaliero Universitaria Ospedale Santa Maria della Misericordia di Udine, Udine, Italy.

[14 ] Hematology, AOU Federico II, Naples, Italy.

[15 ] Hematology-Bone Marrow Transplant Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.

[16 ] Hematology, AO SS Antonio e Biagio e C Arrigo, Alessandria, Italy.

[17 ] Hematology and Bone Marrow Transplant Unit, Azienda ospedaliera San Gerardo, Monza, Italy.

[18 ] Hematology Division-Stem Cell Transplant Unit, Policlinico Tor Vergata, Rome, Italy.

[19 ] Department of Oncology, UOSA Transplant and Cellular Therapy Center, Azienda Ospedaliera Universitaria Senese, Siena, Italy.

[20 ] Hematology and Bone Marrow Transplant Unit, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.

[21 ] Division of Hematology Bone Marrow Transplant & CBB, Chaim Sheba Medical Center, Tel Hashomer, Israel.

[22 ] Unit of Blood Diseases and Stem Cell Transplantation, Department of Clinical and Experimental Sciences, University of Brescia, Spedali Civili of Brescia, Brescia, Italy.

[23 ] Hematology and Bone Marrow Transplant Unit, Fondazione IRCCS Istituto Nazionale Tumori and University of Milano, Milan, Italy.

[24 ] Department of Hematology Oncology, IRCCS Fondazione Policlinico San Matteo & University of Pavia, Pavia, Italy.

[25 ] Department of Cellular Biotechnologies and Hematology, Sapienza University, Rome, Italy.

[26 ] Bone Marrow Transplant Unit, AOR Villa Sofia-Cervello, Palermo, Italy.

[27 ] Hematology, Azienda Ospedaliera S Croce e Carle, Cuneo, Italy.

[28 ] Department of Hematology and Oncology, IRCCS AOU San Martino-IST, Genoa, Italy.

Article

Publisher Item ID: S1470-2045(15)00200-4

DOI: 10.1016/S1470-2045(15)00200-4

PubMed ID: 26429297

SO-VID: 476b5635-9415-4318-96e6-23093caf10d9

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