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DALI: defining antibiotic levels in intensive care unit patients: are current β-lactam antibiotic doses sufficient for critically ill patients?
Jason A Roberts
1 ,
Sanjoy K Paul ,
Murat Akova ,
Matteo Bassetti ,
Jan J De Waele ,
George Dimopoulos ,
Kirsi-Maija Kaukonen ,
Despoina Koulenti ,
Claude Martin ,
Philippe Montravers ,
Jordi Rello ,
Andrew Rhodes ,
Therese Starr ,
Steven C Wallis ,
Jeffrey Lipman
Apr 2014
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Abstract
Morbidity and mortality for critically ill patients with infections remains a global healthcare problem. We aimed to determine whether β-lactam antibiotic dosing in critically ill patients achieves concentrations associated with maximal activity and whether antibiotic concentrations affect patient outcome.