For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
25
views
57
references
 Top references
cited by
26
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      315
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Saffron Aqueous Extract Inhibits the Chemically-induced Gastric Cancer Progression in the Wistar Albino Rat

      research-article

      Read this article at

      ScienceOpenPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Objective(s): Gastric cancer is the first and second leading cause of cancer related death in Iranian men and women, respectively. Gastric cancer management is based on the surgery, radiotherapy and chemotherapy. In the present study, for the first time, the beneficial effect of saffron ( Crocus sativus L.) aqueous extract (SAE) on the 1- Methyl -3 - nitro -1 - nitrosoguanidine (MNNG)-induced gastric cancer in rat was investigated.

          Materials and Methods: MNNG was used to induce gastric cancer and then, different concentrations of SAE were administered to rats. After sacrificing, the stomach tissue was investigated by both pathologist and flow cytometry, and several biochemical parameters was determined in the plasma (or serum) and stomach of rats.

          Results: Pathologic data indicated the induction of cancer at different stages from hyperplasia to adenoma in rats; and the inhibition of cancer progression in the gastric tissue by SAE administration; so that, 20% of cancerous rats treated with higher doses of SAE was completely normal at the end of experiment and there was no rat with adenoma in the SAE treated groups. In addition, the results of the flow cytometry/ propidium iodide staining showed that the apoptosis/proliferation ratio was increased due to the SAE treatment of cancerous rats. Moreover, the significantly increased serum LDH and decreased plasma antioxidant activity due to cancer induction fell backwards after treatment of rats with SAE. But changes in the other parameters (Ca 2+, tyrosine kinase activity and carcino-embryonic antigen) were not significant.

          Conclusion: SAE inhibits the progression of gastric cancer in rats, in a dose dependent manner.

          Related collections

          Most cited references57

          • Record: found
          • Abstract: found
          • Article: not found

          A model for gastric cancer epidemiology.

          P Correa, W Haenszel, C Cuello … (1975)
          It is postulated that one major subtype of gastric carcinoma ("intestinal type") is the end- result of a series of mutations and cell transformation begun in the first decade of life. The mutagen could be a nitroso compound synthesised in the upper gastrointestinal tract by the action of nitrite (i.e., from food or saliva) on naturally occurring nitrogen compounds. Under normal conditions these nitroso compounds do not reach the gastric epithelial cell, presumably because their synthesis is inhibited by antioxidants present in food or because of their inability to pass the mucous barrier. The barrier may be overcome by abrasives or irritants such as hard grains, food with high sodium-chloride concentration, or surfactants. Once the first mutation occurs, the glandular gastric epithelium is gradually changed to intestinal-type epithelium, the mucous barrier altered, and the pH elevated. Under these conditions, bacteria proliferate in the gastric cavity and facilitate the conversion of nitrates to nitrites, thereby increasing the nitrite pool and the probability of formation of mutagenic-carcinogenic nitroso compounds. This process of gastric atrophy and intestinal metaplasia goes on for 30 to 50 years until some of the individuals affected have the final mutation or cell transformation which allows the cell to become autonomous and invade other tissues.
          Article 0 comments Cited 162 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Biomedical properties of saffron and its potential use in cancer therapy and chemoprevention trials.

            F.I. Abdullaev, J.J. Espinosa-Aguirre (2004)
            Chemoprevention strategies are very attractive and have earned serious consideration as potential means of controlling the incidence of cancer. An important element of anticancer drug development using plants is the accumulation and analysis of pertinent experimental data and purported ethnomedical (folkloric) uses for plants. The aim of this review is to provide an updated overview of experimental in vitro and in vivo investigations focused on the anticancer activity of saffron (Crocus sativus L.) and its principal ingredients. Potential use of these natural agents in cancer therapy and chemopreventive trials are also discussed. A computerized search of published articles was performed using the MEDLINE database from 1990 to 2004. Search terms utilized including saffron, carotenoids, chemoprevention, and cancer. All articles were obtained as reprints from their original authors. Additional sources were identified through cross-referencing. Studies in animal models and with cultured human malignant cell lines have demonstrated antitumor and cancer preventive activities of saffron and its main ingredients, possible mechanisms for these activities are discussed. More direct evidence of anticancer effectiveness of saffron as chemopreventive agent may come from trials that use actual reduction of cancer incidence as the primary endpoint This work suggests that future research be warranted that will define the possible use of saffron as effective anticancer and chemopreventive agent in clinical trials.
            Article 0 comments Cited 97 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Crocin, safranal and picrocrocin from saffron (Crocus sativus L.) inhibit the growth of human cancer cells in vitro.

              Julio Escribano, Gonzalo-Luis Alonso, Miguel Coca-Prados … (1996)
              Extracts of saffron (Crocus sativus L.) have been reported to inhibit cell growth of human tumor cells. In order to study the cytotoxic effect of the characteristic compounds of saffron spice, we have isolated crocin, crocetin, picrocrocin and safranal. Doses inducing 50% cell growth inhibition (LD50) on HeLa cells were 2.3 mg/ml for an ethanolic extract of saffron dry stigmas, 3 mM for crocin, 0.8 mM for safranal and 3 mM for picrocrocin. Crocetin did not show cytotoxic effect. Cells treated with crocin exhibited wide cytoplasmic vacuole-like areas, reduced cytoplasm, cell shrinkage and pyknotic nuclei, suggesting apoptosis induction. Considering its water-solubility and high inhibitory growth effect, crocin is the more promising saffron compound to be assayed as a cancer therapeutic agent.
              Article 0 comments Cited 72 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): Iran J Basic Med Sci
                Journal ID (iso-abbrev): Iran J Basic Med Sci
                Journal ID (publisher-id): IJBMS
                Title: Iranian Journal of Basic Medical Sciences
                Publisher: Mashhad University of Medical Sciences (Mashhad, Iran )
                ISSN (Print): 2008-3866
                ISSN (Electronic): 2008-3874
                Publication date (Print): January 2013
                Volume: 16
                Issue: 1
                Pages: 27-38
                Affiliations
                [1 ]Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
                [2 ]Department of Biology, Faculty of Sciences, Zabol University, Zabol, Iran
                [3 ]The Cancer Institute, Imam Khomeini University Hospital, Tehran University of Medical Sciences, Tehran, Iran
                [4 ]Department of Medical Physics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
                [5 ]Department of Pathology, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran
                Author notes
                [* ]Corresponding author: S. Zahra Bathaie, Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University (TMU), Tehran, Iran. Tel: +98-21-8288-3851; Fax: +98-21-82884555; email: bathai_z@modares.ac.ir or zbatha2000@yahoo.com
                Article
                Publisher ID: IJBMS-16-027
                PMC ID: 3637902
                PubMed ID: 23638290
                SO-VID: 46feb3dd-9933-4707-892e-ae491c500945
                Copyright © © 2013: Iranian Journal of Basic Medical Sciences
                License:

                This is an Open Access article distributed under the terms of the Creative Commons Attribution License, ( http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 30 May 2012
                Date accepted : 10 October 2012
                Categories
                Subject: Original Article

                Keywords: anticancer,crocus sativus,flow cytometry,ldh,mnng,saffron
                Data availability:
                Keywords: anticancer, crocus sativus, flow cytometry, ldh, mnng, saffron

                Comments

                Comment on this article

                Similar content315

                See all similar

                Cited by25

                See all cited by

                Most referenced authors672

                See all reference authors