MiR-145 and miR-203 represses TGF-β-induced epithelial-mesenchymal transition and invasion by inhibiting SMAD3 in non-small cell lung cancer cells.

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Abstract

MicroRNAs (miRNAs) have been proved to play important role in development of various cancers, including non-small cell lung cancer (NSCLC). Our previous studies have shown that miR-203 and miR-145 are associated with cellular invasion in NSCLC and nasopharyngeal cancer, respectively. However, the mechanistic role of miR-203 and miR-145 in TGF-β-induced epithelial-mesenchymal transition (EMT) has not yet been elucidated in human cancers, including NSCLC.

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Author and article information

Journal

Journal ID (iso-abbrev): Lung Cancer

Title: Lung cancer (Amsterdam, Netherlands)

Publisher: Elsevier BV

ISSN (Electronic): 1872-8332

ISSN (Print): 0169-5002

Publication date (Electronic): Jul 2016

Volume: 97

Affiliations

[1 ] Department of Thoracic and Cardiovascular Surgery, The First Affiliated Hospital of Soochow University, Medical College of Soochow University, Suzhou 215006, China; Department of Cardiothoracic Surgery, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an 223200, China.

[2 ] Department of Thoracic and Cardiovascular Surgery, The First Affiliated Hospital of Soochow University, Medical College of Soochow University, Suzhou 215006, China.

[3 ] Soochow University Laboratory of Cancer Molecular Genetics, Medical College of Soochow University, Suzhou 215123, China; Suzhou Key Laboratory for Molecular Cancer Genetics, Suzhou 215123, China.

[4 ] Soochow University Laboratory of Cancer Molecular Genetics, Medical College of Soochow University, Suzhou 215123, China; Suzhou Key Laboratory for Molecular Cancer Genetics, Suzhou 215123, China. Electronic address: htzhang@suda.edu.cn.

[5 ] Department of Thoracic and Cardiovascular Surgery, The First Affiliated Hospital of Soochow University, Medical College of Soochow University, Suzhou 215006, China; Suzhou Key Laboratory for Molecular Cancer Genetics, Suzhou 215123, China. Electronic address: zhaojia0327@126.com.

Article

Publisher Item ID: S0169-5002(16)30300-2

DOI: 10.1016/j.lungcan.2016.04.017

PubMed ID: 27237033

SO-VID: 46934033-50e4-4c8e-9fa9-b4726338ea21

History

Keywords: Epithelial-mesenchymal transition,MiR-145,MiR-203,SMAD3

Data availability:

Keywords: Epithelial-mesenchymal transition, MiR-145, MiR-203, SMAD3

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