Cigarette smoke augments MUC5AC production via the TLR3-EGFR pathway in airway epithelial cells.

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Abstract

Viral infections are a major cause of chronic obstructive pulmonary disease (COPD) exacerbations. Toll-like receptor 3 (TLR3) reacts with double-stranded RNA (dsRNA) and participates in the immune response after viral infection. In the present study, we examined whether cigarette smoke, which is involved in the pathogenesis of COPD, enhances mucin production via the TLR3-epidermal growth factor receptor (EGFR) pathway in airway epithelial cells.

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Author and article information

Journal

Journal ID (iso-abbrev): Respir Investig

Title: Respiratory investigation

Publisher: Elsevier BV

ISSN (Electronic): 2212-5353

ISSN (Print): 2212-5345

Publication date (Electronic): Jul 2015

Volume: 53

Issue: 4

Affiliations

[1 ] Third Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan. Electronic address: kanaik@wakayama-med.ac.jp.

[2 ] Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan. Electronic address: koarai@rm.med.tohoku.ac.jp.

[3 ] Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan. Electronic address: Yutaka.Sisikura@mc2.seikyou.ne.jp.

[4 ] Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan. Electronic address: sugiura@rm.med.tohoku.ac.jp.

[5 ] Third Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan. Electronic address: 1kawa@wakayama-med.ac.jp.

[6 ] Third Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan. Electronic address: kikuchi@wakayama-med.ac.jp.

[7 ] Third Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan. Electronic address: akamatsu@wakayama-med.ac.jp.

[8 ] Third Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan. Electronic address: tsuna@wakayama-med.ac.jp.

[9 ] Third Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan. Electronic address: masa-n@wakayama-med.ac.jp.

[10 ] Third Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan. Electronic address: kazmatsu@wakayama-med.ac.jp.

[11 ] Third Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan. Electronic address: minakaty@wakayama-med.ac.jp.

[12 ] Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan. Electronic address: ichinose@rm.med.tohoku.ac.jp.

Article

Publisher Item ID: S2212-5345(15)00011-8

DOI: 10.1016/j.resinv.2015.01.007

PubMed ID: 26100173

SO-VID: 46452906-5db7-4c14-8c96-98077d00a108

History

Keywords: Mucin,Oxidative stress,Toll-like receptor 3,COPD,Exacerbation

Data availability:

Keywords: Mucin, Oxidative stress, Toll-like receptor 3, COPD, Exacerbation

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