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      Care Gaps and Recommendations in Vestibular Migraine: An Expert Panel Summit

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          Abstract

          Vestibular migraine (VM) is an increasingly recognized pathology yet remains as an underdiagnosed cause of vestibular disorders. While current diagnostic criteria are codified in the 2012 Barany Society document and included in the third edition of the international classification of headache disorders, the pathophysiology of this disorder is still elusive. The Association for Migraine Disorders hosted a multidisciplinary, international expert workshop in October 2020 and identified seven current care gaps that the scientific community needs to resolve, including a better understanding of the range of symptoms and phenotypes of VM, the lack of a diagnostic marker, a better understanding of pathophysiologic mechanisms, as well as the lack of clear recommendations for interventions (nonpharmacologic and pharmacologic) and finally, the need for specific outcome measures that will guide clinicians as well as research into the efficacy of interventions. The expert group issued several recommendations to address those areas including establishing a global VM registry, creating an improved diagnostic algorithm using available vestibular tests as well as others that are in development, conducting appropriate trials of high quality to validate current clinically available treatment and fostering collaborative efforts to elucidate the pathophysiologic mechanisms underlying VM, specifically the role of the trigemino-vascular pathways.

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          Most cited references94

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          Epidemiology of benign paroxysmal positional vertigo: a population based study.

          To examine the prevalence and incidence, clinical presentation, societal impact and comorbid conditions of benign paroxysmal positional vertigo (BPPV) in the general population. Cross-sectional, nationally representative neurotological survey of the general adult population in Germany with a two stage sampling design: screening of 4869 participants from the German National Telephone Health Interview Survey 2003 (response rate 52%) for moderate or severe dizziness or vertigo, followed by validated neurotological interviews (n = 1003; response rate 87%). Diagnostic criteria for BPPV were at least five attacks of vestibular vertigo lasting <1 min without concomitant neurological symptoms and invariably provoked by typical changes in head position. In a concurrent validation study (n = 61) conducted in two specialised dizziness clinics, BPPV was detected by our telephone interview with a specificity of 92% and a sensitivity of 88% (positive predictive value 88%, negative predictive value 92%). BPPV accounted for 8% of individuals with moderate or severe dizziness/vertigo. The lifetime prevalence of BPPV was 2.4%, the 1 year prevalence was 1.6% and the 1 year incidence was 0.6%. The median duration of an episode was 2 weeks. In 86% of affected individuals, BPPV led to medical consultation, interruption of daily activities or sick leave. In total, only 8% of affected participants received effective treatment. On multivariate analysis, age, migraine, hypertension, hyperlipidaemia and stroke were independently associated with BPPV. BPPV is a common vestibular disorder leading to significant morbidity, psychosocial impact and medical costs.
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            Vestibular migraine: diagnostic criteria.

            This paper presents diagnostic criteria for vestibular migraine, jointly formulated by the Committee for Classification of Vestibular Disorders of the Bárány Society and the Migraine Classification Subcommittee of the International Headache Society (IHS). The classification includes vestibular migraine and probable vestibular migraine. Vestibular migraine will appear in an appendix of the third edition of the International Classification of Headache Disorders (ICHD) as a first step for new entities, in accordance with the usual IHS procedures. Probable vestibular migraine may be included in a later version of the ICHD, when further evidence has been accumulated. The diagnosis of vestibular migraine is based on recurrent vestibular symptoms, a history of migraine, a temporal association between vestibular symptoms and migraine symptoms and exclusion of other causes of vestibular symptoms. Symptoms that qualify for a diagnosis of vestibular migraine include various types of vertigo as well as head motion-induced dizziness with nausea. Symptoms must be of moderate or severe intensity. Duration of acute episodes is limited to a window of between 5 minutes and 72 hours.
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              Migraine

              Migraine affects an estimated 12% of the population. Global estimates are higher. Chronic migraine (CM) affects 1% to 2% of the global population. Approximately 2.5% of persons with episodic migraine progress to CM. Several risk factors are associated with the progression to CM. There is significant short-term variability in migraine frequency independent of treatment. Migraine is associated with cardiovascular disease, psychiatric disease, and sleep disorders. It is the second most disabling condition worldwide. CM is associated with higher headache-related disability/impact, medical and psychiatric comorbidities, health care resource use, direct and indirect costs, lower socioeconomic status, and health-related quality of life.
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                Author and article information

                Contributors
                Journal
                Front Neurol
                Front Neurol
                Front. Neurol.
                Frontiers in Neurology
                Frontiers Media S.A.
                1664-2295
                03 January 2022
                2021
                : 12
                : 812678
                Affiliations
                [1] 1Department of Research, Association of Migraine Disorders , North Kingstown, RI, United States
                [2] 2Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina , Charleston, SC, United States
                [3] 3Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins University School of Medicine , Baltimore, MD, United States
                [4] 4Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center , Dallas, TX, United States
                [5] 5Department of Otolaryngology-Head and Neck Surgery, University of California, Irvine , Irvine, CA, United States
                [6] 6Department of Otolaryngology, Keck School of Medicine, University of Southern California , Los Angeles, CA, United States
                [7] 7Department of Otolaryngology, University of Miami Miller School of Medicine , Miami, FL, United States
                [8] 8Jefferson Headache Center, Thomas Jefferson University , Philadelphia, PA, United States
                [9] 9Department of Otolaryngology-Head and Neck Surgery, Mass Eye & Ear and Harvard Medical School , Boston, MA, United States
                [10] 10Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine , Saint Louis, MO, United States
                [11] 11Department of Research, Bayview Physicians Group , Chesapeake, VA, United States
                [12] 12Biomedical Engineering and Neuroscience, University of Rochester Medical Center , Rochester, NY, United States
                [13] 13Otolaryngology Unit, University of Siena , Siena, Italy
                [14] 14Department of Otolaryngology, Head and Neck Surgery, Laryngological Oncology, Nicolaus Copernicus University , Torun, Poland
                [15] 15Department of Otolaryngology, San Raffaele Scientific Hospital , Milan, Italy
                [16] 16Neurology and Stroke Unit, ASST Sette Laghi, Circolo Hospital , Varese, Italy
                [17] 17Department of Speech-Language Pathology & Audiology, Towson University , Towson, MD, United States
                Author notes

                Edited by: Jeffrey P. Staab, Mayo Clinic, United States

                Reviewed by: Vincenzo Marcelli, Local Health Authority Naples 1 Center, Italy; Giuseppe Chiarella, University of Catanzaro, Italy

                *Correspondence: Monica P. Mallampalli monica@ 123456migrainecollaborative.org

                This article was submitted to Neuro-Otology, a section of the journal Frontiers in Neurology

                †These authors have contributed equally to this work and share first authorship

                ‡These authors have contributed equally to this work and share last authorship

                §These authors share senior authorship

                Article
                10.3389/fneur.2021.812678
                8762211
                35046886
                462a3ff3-59f5-41af-859f-0404f6f90d11
                Copyright © 2022 Mallampalli, Rizk, Kheradmand, Beh, Abouzari, Bassett, Buskirk, Ceriani, Crowson, Djalilian, Goebel, Kuhn, Luebke, Mandalà, Nowaczewska, Spare, Teggi, Versino, Yuan, Zaleski-King, Teixido and Godley.

                This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

                History
                : 10 November 2021
                : 29 November 2021
                Page count
                Figures: 0, Tables: 2, Equations: 0, References: 94, Pages: 10, Words: 8998
                Categories
                Neurology
                Review

                Neurology
                vestibular migraine,chronic migraine (cm),trigemino-vascular pathway,vertigo-pathophysiology,vestibular disorders

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