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      Laser Excision of Focal Epithelial Hyperplasia (Heck's Disease): A Rare Case Report

      case-report

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          ABSTRACT

          Heck's disease or focal epithelial hyperplasia is a rare, benign and asymptomatic lesion of oral mucosa that is characterized by the presence of soft, sessile papules, white to pinkish in colour that occur diffusely in oral cavity. Prevalence rate of this disease greatly varies from one geographic region to another. It is found to be closely associated with human papilloma virus (HPV). This paper reports an Indian case of focal epithelial hyperplasia in a 5-year-old boy that is diagnosed according to both clinical and histopathological features, where human poillomavirus (HPV) subtype 32 was found associated with disease through polymerase chain reaction analyses. A dental practitioner should be aware of this disease and must perform a careful evaluation both clinically and histopathologically for setting the diagnosis with other diseases.

          How to cite this article

          Nallanchakrava S, Sreebala N, Basavaraj, Sindgi F. Laser Excision of Focal Epithelial Hyperplasia (Heck's Disease): A Rare Case Report. Int J Clin Pediatr Dent, 2018;11(6):526-528

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          Association of HLA-DR4 (DRB1*0404) with human papillomavirus infection in patients with focal epithelial hyperplasia.

          C Corona, Michael Morales, Julio Granados … (2004)
          To determine gene frequencies of HLA-DR alleles in 22 Mexican patients with focal epithelial hyperplasia and compare them with those present in ethnically matched healthy subjects, as well as to determine the types of human papillomavirus present in the lesions. Prospective and retrospective observational study. Dermatology outpatient clinic in a general hospital. Twenty-two patients with clinically and histologically confirmed focal epithelial hyperplasia seen within a 10-year period. None. Results of high-resolution DNA typing for HLA-DR alleles and biopsy for viral typing. HLA-DR4 (DRB1*0404) was significantly increased (P<.001; odds ratio, 3.9; 95% confidence interval, 1.86-8.03). Seventeen (85%) of 20 patients had human papillomavirus subtype 13. The data on human papillomavirus differed from reports elsewhere that described association with human papillomavirus type 32. The HLA-DRB1*0404 allele suggests that Amerindian populations are at risk, and in this group, the Mexican population studied was affected only by human papillomavirus type 13.
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            Oral focal epithelial hyperplasia: report of five cases

            Cristina Maria Borborema-Santos, Maria Castro, Paulo José Benevides dos Santos … (2006)
            Focal epithelial hyperplasia or Heck's disease is a rare contagious disease caused by human papillomavirus types 13 or 32, initially described among Native American populations. This condition is characterized by the occurrence of multiple small papules or nodules in oral cavity, especially on labial and buccal mucosa and tongue. This report describes the diagnosis of focal epithelial hyperplasia in five Central Amazonian Indians who sought treatment at the Amazonas State Foundation of Tropical Medicine (FMT-AM), using clinical criteria, polymerase chain reaction (PCR) and DNA sequencing.
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              A Case Report of Focal Epithelial Hyperplasia (Heck's disease) with PCR Detection of Human Papillomavirus.

              Bora Ozden, Kaan Gunduz, Ömer Günhan … (2011)
              Focal epithelial hyperplasia or Heck's disease, is a rare viral infection of the oral mucosa caused by human papillomavirus. The frequency of this disease varies widely from one geographic region to another. In Caucasians there have been only few cases reported. This paper reports a case of focal epithelial hyperplasia and demonstrates the association with HPV subtype 32 through polymerase chain reaction (PCR) and sequencing of PCR products. A 7-year-old Caucasian girl was admitted to our clinic for investigation of multiple oral mucosal lesions in the mouth. Lesion was excised under local anesthesia without any complication. The lesion was diagnosed as focal epithelial hyperplasia according to both clinical and histopathological features. Dental staff should be aware of these kind of lesions and histopathological examination together with a careful clinical observation should be carried out for a definitive diagnosis.
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                Author and article information

                Contributors
                Srinivas Nallanchakrava: Role: Professor
                Naga Sreebala: Role: Reader
                Basavaraj: Role: Postgraduate Student
                Farheena Sindgi: Role: Postgraduate Student
                Journal
                Journal ID (nlm-ta): Int J Clin Pediatr Dent
                Journal ID (iso-abbrev): Int J Clin Pediatr Dent
                Journal ID (publisher-id): IJCPD
                Title: International Journal of Clinical Pediatric Dentistry
                Publisher: Jaypee Brothers Medical Publishers
                ISSN (Print): 0974-7052
                ISSN (Electronic): 0975-1904
                Publication date (Print): Nov-Dec 2018
                Volume: 11
                Issue: 6
                Pages: 526-528
                Affiliations
                [1-4 ] Department of Pedodontics and Preventive Dentistry, Panineeya Mahavidyalaya Institute of Dental Sciences and Research Centre, Hyderabad, Telangana, India
                Author notes
                Srinivas Nallanchakrava, Professor, Department of Pedodontics and Preventive Dentistry, Panineeya Mahavidyalaya Institute of Dental Sciences and Research Centre, Hyderabad, Telangana, India, e-mail: cnudent@ 123456gmail.com
                Article
                DOI: 10.5005/jp-journals-10005-1569
                PMC ID: 6611530
                PubMed ID: 31303742
                SO-VID: 45443d20-6d3f-4526-a4bb-fdf162573c3f
                Copyright © Copyright © 2018; Jaypee Brothers Medical Publishers (P) Ltd.
                License:

                This work is licensed under a Creative Commons Attribution 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/

                History
                Categories
                Subject: Case Report

                Keywords: focal epithelial hyperplasia,heck's disease,human papilloma virus
                Data availability:
                Keywords: focal epithelial hyperplasia, heck's disease, human papilloma virus

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