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      A viscoelastic analysis of the P56 mouse brain under large-deformation dynamic indentation.

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          Abstract

          The brain is a complex organ made up of many different functional and structural regions consisting of different types of cells such as neurons and glia, as well as complex anatomical geometries. It is hypothesized that the different regions of the brain exhibit significantly different mechanical properties which may be attributed to the diversity of cells within individual brain regions. The regional viscoelastic properties of P56 mouse brain tissue, up to 70μm displacement, are presented and discussed in the context of traumatic brain injury, particularly how the different regions of the brain respond to mechanical loads. Force-relaxation data obtained from micro-indentation measurements were fit to both linear and quasi-linear viscoelastic models to determine the time and frequency domain viscoelastic response of the pons, cortex, medulla oblongata, cerebellum, and thalamus. The damping ratio of each region was also determined. Each region was found to have a unique mechanical response to the applied displacement, with the pons and thalamus exhibiting the largest and smallest force-response, respectively. All brain regions appear to have an optimal frequency for the dissipation of energies which lies between 1 and 10Hz.

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          Author and article information

          Journal
          Acta Biomater
          Acta biomaterialia
          Elsevier BV
          1878-7568
          1742-7061
          Jan 15 2017
          : 48
          Affiliations
          [1 ] School of Mechanical & Materials Engineering, University College Dublin, Dublin, Ireland. Electronic address: david.mac-manus@ucdconnect.ie.
          [2 ] School of Mechanical & Materials Engineering, University College Dublin, Dublin, Ireland. Electronic address: baptiste.pierrat@emse.fr.
          [3 ] Department of Mechanical & Manufacturing Engineering, Dublin City University, Dublin, Ireland. Electronic address: jeremiah.murphy@dcu.ie.
          [4 ] School of Mechanical & Materials Engineering, University College Dublin, Dublin, Ireland. Electronic address: michael.gilchrist@ucd.ie.
          Article
          S1742-7061(16)30556-6
          10.1016/j.actbio.2016.10.029
          27777117
          44af97fb-2ea5-4e69-8c14-6e97c7ad64da
          History

          Prony,Dynamic modulus,Traumatic brain injury,neo-Hookean,Damping ratio

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