- Record: found
- Abstract: found
- Article: not found
M2a macrophage can rescue proliferation and gene expression of benign prostate hyperplasia epithelial and stroma cells from insulin-like growth factor 1 knockdown.
Qiaofeng Qian
1 ,
Weixiang He
1 ,
Daoquan Liu
1 ,
Jing Yin
2 ,
Linpeng Ye
3 ,
Ping Chen
1 ,
Deqiang Xu
1 ,
Jianmin Liu
1 ,
Yan Li
1 ,
Guang Zeng
1 ,
Mingzhou Li
1 ,
Zhonghua Wu
1 ,
Yingao Zhang
1 ,
Xinghuan Wang
1 ,
Michael E DiSanto
4 ,
Xinhua Zhang
1
June 2021
There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
Benign prostatic hyperplasia (BPH) is a common disease in elderly men and is often accompanied by chronic inflammation. Macrophages (several subtypes) are the main inflammatory cells that infiltrate the hyperplastic prostate and are found to secrete cytokines and growth factors. The current study aims to explore the effect of M2a macrophages on the development of BPH via insulin-like growth factor 1 (IGF-1).