Introduction
Biologics such as dupilumab are a highly efficacious and relatively safe treatment
option for patients with recalcitrant immune-mediated disease; however, because of
their modulation of the immune system, biologics have been associated with severe
infections, including reactivation of latent hepatitis B virus (HBV).1, 2, 3 As a
result of the increased morbidity and mortality associated with active HBV, physicians
are often reluctant to prescribe biologics in patients with chronic HBV infection.
Dupilumab is the first biologic therapy approved for the treatment of moderate-to-severe
atopic dermatitis (AD).
4
We present 2 cases of patients with AD and chronic HBV treated with dupilumab while
receiving concomitant therapy for HBV.
Case 1
The patient is 40-year-old man with a lifelong history of severe, generalized AD and
chronic HBV via vertical transmission. He presented to our clinic in March 2015 with
worsening pruritus and ill-defined erythematous, scaly plaques of the head, neck,
trunk, and extremities. The patient was treated with clobetasol, triamcinolone, and
mometasone creams with poor response. Because of his concomitant HBV infection, the
patient was evaluated by a hepatologist before initiation of a systemic immunosuppressant.
His HBV evaluation found normal liver enzyme levels and liver function tests and an
HBV viral load of 19,120 IU/mL (alanine aminotransferase, 30 IU/L; aspartate aminotransferase,
34 IU/L; alkaline phosphatase, 55 IU/L; total bilirubin, 0.4 mg/dL; albumin, 4.1 g/dL).
An abdominal computed tomography scan found no evidence of advanced liver disease
or liver lesions, and a FibroScan showed no evidence of liver fibrosis.
The patient was simultaneously started on entecavir and cyclosporine. He had excellent
virologic response to entecavir, and subsequent viral loads were undetectable. Laboratory
monitoring occurred every 3 months and was reduced to every 6 months after viral loads
became undetectable. After inadequate treatment with cyclosporine for 1 year, dupilumab
was initiated, and the patient continued on cyclosporine and topical therapies as
needed. His lesions improved significantly within 12 weeks, and cyclosporine was tapered.
After 20 months of treatment, his disease remains well controlled on dupilumab monotherapy,
he experienced no adverse events, and he maintained normal liver function levels with
an undetectable HBV viral load.
Case 2
The patient is a 73-year-old man with a longstanding history of severe, refractory
AD, a 15-year history of prurigo nodularis, and chronic HBV well controlled on entecavir
with an undetectable viral load. He first presented to our clinic in May 2011 with
diffuse, erythematous plaques with lichenification of the torso and extremities. On
examination, he was also found to have prurigo nodules that were erythematous with
excoriations and hemorrhagic crusts of the upper and lower extremities. His AD and
prurigo nodularis were poorly controlled with topical treatments, phototherapy, and
Goeckerman therapy. The patient was evaluated by the hepatology department and found
to have no impairment of liver function (aspartate aminotransferase, 48; alanine aminotransferase,
26; alkaline phosphatase, 78; total bilirubin, 0.8) and an undetectable viral load.
Abdominal computed tomography scan and FibroScan found no evidence of advanced liver
disease. He was started on dupilumab with concurrent Goeckerman therapy and topical
treatments. The hepatology department monitored the patient monthly, which was reduced
to every 3 months when viral loads remained undetectable. The patient achieved excellent
results within 12 weeks with a significant reduction in lesions and pruritus. He was
treated with dupilumab monotherapy for 12 months with no adverse events. His liver
function tests remained within normal limits, and his viral load was undetectable
throughout his treatment (Fig 1).
Fig 1
Clinical response of atopic dermatitis to dupilumab therapy. A, Week 4 of dupilumab
treatment. B, Week 12 of dupilumab treatment.
Discussion
HBV affects 847,000 to 2.2 million people in the United States and more than 400 million
people worldwide.
1
It can cause complications of fulminant hepatitis, cirrhosis, hepatocellular carcinoma,
and even death.3, 5 Because of the increased morbidity and mortality associated with
HBV reactivation and the increasing prevalence of biologics, it is of utmost importance
to define their safety profile in patients with positive HBV serology.
6
Dupilumab, the first biologic therapy for AD, is a fully human monoclonal antibody
directed against the α subunit of the interleukin (IL)-4 receptor. It blocks the downstream
effects of IL-4 and IL-13, key drivers of type 2-helper T-cell–mediated inflammation.
4
Its safety in patients with chronic HBV is not known, and, to our knowledge, this
is the first report describing the use of dupilumab in patients with concomitant HBV.
IL-4 is a pleiotropic anti-inflammatory cytokine that is known to play an important
role in the in the modulation of the hepatic immune system. The α subunit of the IL-4
receptor has been reported to promote liver regeneration through hepatocyte proliferation
7
and regulate both the progression and reversal of liver fibrosis,
8
and specific IL-4 genotypes have been associated with the development of chronic HBV
after initial HBV infection.9, 10 Additionally, IL-4 has also been implicated in the
progression to cirrhosis in patients with HBV.
10
Because of this involvement in the pathogenesis of chronic HBV and its associated
complications and the potential lower immunocompetence of patients on biologics, the
decision to initiate dupilumab should be made with careful consideration and in collaboration
with a hepatologist. Additionally, prophylaxis with antivirals should be considered
to prevent a catastrophic hepatitis flare, liver failure, or HBV reactivation in the
setting of immunomodulation therapy for AD.
We presented 2 cases of patients with concomitant HBV on entecavir, treated with dupilumab.
Initiation of dupilumab was made after consultation and evaluation by a hepatologist
with close surveillance of liver function and HBV status before and during treatment.
The patients achieved significant improvement of their recalcitrant symptoms with
no evidence of hepatitis or HBV reactivation, as determined by normal laboratory values
and an undetectable viral load. Our patients had a positive response to dupilumab,
and the treatment was well tolerated when combined with concomitant entecavir therapy
and close monitoring of liver function and HBV status.