Vitamin D in children with growth hormone deficiency due to pituitary stalk interruption syndrome

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Background

Recent studies have shown a relationship between vitamin D status and growth hormone (GH) and insulin-like growth factor 1 (IGF1). The objective of this study was to assess vitamin D status in children with GH deficiency due to pituitary stalk interruption syndrome (PSIS) and to investigate the relationship between 25-hydroxyvitamin D (25OHD) and 1,25-dihydroxyvitamin D (1,25 (OH) ₂D) serum levels and patient characteristics.

Methods

A retrospective single-center study of 25OHD and 1,25(OH) ₂D serum concentrations in 50 children with PSIS at the initial evaluation before treatment.

Results

Mean concentrations of 33.2 ± 18.0 ng/mL for 25OHD and 74.5 ± 40.7 ng/L for 1,25(OH) ₂D were measured. Additionally, 25OHD concentrations were significantly higher in boys than in girls ( p = 0.04) and lower in the cold season than in the sunny season ( p = 0.03). Significant positive correlations were observed between the GH peak and serum 1,25 (OH) ₂D concentrations (Rho = 0.35; p = 0.015) and the 1,25(OH) ₂D/25OHD ratio (Rho = 0.29; p < 0.05). No correlation was found for other characteristics, including IGF1.

Conclusions

Vitamin D status in children with hypothalamic-pituitary deficiency due to PSIS was similar to that reported in national and European studies in healthy children. The positive significant correlations between the GH peak and the 1,25 (OH) ₂D concentration as well as with the 1,25 (OH) ₂D/25OHD ratio suggest that even in these patients who had severely impaired GH secretion and low IGF1 levels, an interplay between the GH/IGF1 axis and the vitamin D system still exists.

Related collections

Most cited references 29

Record: found
Abstract: found
Article: not found

Relation of vitamin D deficiency to cardiovascular risk factors, disease status, and incident events in a general healthcare population.

Jeffrey L. Anderson, Heidi T May, Benjamin D. Horne … (2010)

Vitamin D recently has been proposed to play an important role in a broad range of organ functions, including cardiovascular (CV) health; however, the CV evidence-base is limited. We prospectively analyzed a large electronic medical records database to determine the prevalence of vitamin D deficiency and the relation of vitamin D levels to prevalent and incident CV risk factors and diseases, including mortality. The database contained 41,504 patient records with at least one measured vitamin D level. The prevalence of vitamin D deficiency (≤30 ng/ml) was 63.6%, with only minor differences by gender or age. Vitamin D deficiency was associated with highly significant (p <0.0001) increases in the prevalence of diabetes, hypertension, hyperlipidemia, and peripheral vascular disease. Also, those without risk factors but with severe deficiency had an increased likelihood of developing diabetes, hypertension, and hyperlipidemia. The vitamin D levels were also highly associated with coronary artery disease, myocardial infarction, heart failure, and stroke (all p <0.0001), as well as with incident death, heart failure, coronary artery disease/myocardial infarction (all p <0.0001), stroke (p = 0.003), and their composite (p <0.0001). In conclusion, we have confirmed a high prevalence of vitamin D deficiency in the general healthcare population and an association between vitamin D levels and prevalent and incident CV risk factors and outcomes. These observations lend strong support to the hypothesis that vitamin D might play a primary role in CV risk factors and disease. Given the ease of vitamin D measurement and replacement, prospective studies of vitamin D supplementation to prevent and treat CV disease are urgently needed. Copyright © 2010 Elsevier Inc. All rights reserved.

0 comments Cited 189 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Vitamin D and musculoskeletal health, cardiovascular disease, autoimmunity and cancer: Recommendations for clinical practice.

Jean-Claude Souberbielle, Jean-Jacques Body, Joan Lappe … (2010)

There is increasing evidence that, in addition to the well-known effects on musculoskeletal health, vitamin D status may be related to a number of non-skeletal diseases. An international expert panel formulated recommendations on vitamin D for clinical practice, taking into consideration the best evidence available based on published literature today. In addition, where data were limited to smaller clinical trials or epidemiologic studies, the panel made expert-opinion based recommendations. Twenty-five experts from various disciplines (classical clinical applications, cardiology, autoimmunity, and cancer) established draft recommendations during a 2-day meeting. Thereafter, representatives of all disciplines refined the recommendations and related texts, subsequently reviewed by all panelists. For all recommendations, panelists expressed the extent of agreement using a 5-point scale. Recommendations were restricted to clinical practice and concern adult patients with or at risk for fractures, falls, cardiovascular or autoimmune diseases, and cancer. The panel reached substantial agreement about the need for vitamin D supplementation in specific groups of patients in these clinical areas and the need for assessing their 25-hydroxyvitamin D (25(OH)D) serum levels for optimal clinical care. A target range of at least 30 to 40 ng/mL was recommended. As response to treatment varies by environmental factors and starting levels of 25(OH)D, testing may be warranted after at least 3 months of supplementation. An assay measuring both 25(OH)D(2) and 25(OH)D(3) is recommended. Dark-skinned or veiled individuals not exposed much to the sun, elderly and institutionalized individuals may be supplemented (800 IU/day) without baseline testing. Copyright 2010 Elsevier B.V. All rights reserved.

0 comments Cited 142 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Body Mass Index variations: centiles from birth to 87 years.

F Rolland, A Charraud, M Sempé … (1990)

This report provides Body Mass Index (weight/height2) values for the French population from birth to the age of 87 years. BMI curves increase during the first year, decrease until the age of 6, increase again up to 65 years and decrease thereafter. These variations reflect the total changes of fat body mass during life. The 50th centile values of Wt/Ht2 at the ages of 20, 40, 60, 80 years are 21.5, 24.6, 25.4, 24.4 kg/m2 for men and 20.6, 22.6, 24.1, 23.4 kg/m2 for women. The values for the 3rd, 50th and 97th centiles in the middle years are approximately 18, 24 and 32 kg/m2. Graphs for these and four other percentiles are plotted against age, and two other graphs summarising the variation and skewness of the Wt/Ht2 distribution are provided to calculate exact percentiles and Z-scores for individuals.

0 comments Cited 98 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Contributors

Cécile Delecroix: ceciledelecroix88@gmail.com

Raja Brauner: raja.brauner@wanadoo.fr

Jean-Claude Souberbielle: jean-claude.souberbielle@aphp.fr

Journal

Journal ID (nlm-ta): BMC Pediatr

Journal ID (iso-abbrev): BMC Pediatr

Title: BMC Pediatrics

Publisher: BioMed Central (London )

ISSN (Electronic): 1471-2431

Publication date (Electronic): 24 January 2018

Publication date PMC-release: 24 January 2018

Publication date Collection: 2018

Volume: 18

Electronic Location Identifier: 11

Affiliations

[1 ]ISNI 0000 0001 2177 525X, GRID grid.417888.a, Fondation Ophtalmologique Adolphe de Rothschild and Université Paris Descartes, ; Paris, France

[2 ]ISNI 0000 0004 0593 9113, GRID grid.412134.1, Assistance Publique-Hôpitaux de Paris, Hôpital Necker-Enfants Malades, Service d’Explorations Fonctionnelles, ; Paris, France

Article

Publisher ID: 992

DOI: 10.1186/s12887-018-0992-3

PMC ID: 5784716

PubMed ID: 29368588

SO-VID: 43c95941-ed86-4ab8-8de3-02afa7265234

License:

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

History

Date received : 23 May 2017

Date accepted : 17 January 2018

Custom metadata

ScienceOpen disciplines: Pediatrics

Keywords: 1,25(oh)2d,1,25-dihydroxyvitamin d,25ohd,25-hydroxyvitamin d,growth hormone,growth hormone deficiency,insulin-like growth factor 1,pituitary stalk interruption syndrome,vitamin d

Data availability:

ScienceOpen disciplines: Pediatrics

Keywords: 1,25(oh)2d, 1,25-dihydroxyvitamin d, 25ohd, 25-hydroxyvitamin d, growth hormone, growth hormone deficiency, insulin-like growth factor 1, pituitary stalk interruption syndrome, vitamin d

Vitamin D in children with growth hormone deficiency due to pituitary stalk interruption syndrome

Read this article at

Abstract

Background

Methods

Results

Conclusions

Related collections

Cures Within Reach: Autoimmune Lymphoproliferative Syndrome (ALPS)

Most cited references 29

Relation of vitamin D deficiency to cardiovascular risk factors, disease status, and incident events in a general healthcare population.

Vitamin D and musculoskeletal health, cardiovascular disease, autoimmunity and cancer: Recommendations for clinical practice.

Body Mass Index variations: centiles from birth to 87 years.

Author and article information

Contributors

Journal

Affiliations

Article

History

Categories

Custom metadata

Comments

Comment on this article

Similar content 174

Cited by 4

Most referenced authors 750