Regenerative immunology: the immunological reaction to biomaterials

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Abstract

<p id="P2">Regenerative medicine promises to meet two of the most urgent needs of modern organ transplantation, namely immunosuppression-free transplantation and an inexhaustible source of organs. Ideally, bioengineered organs would be manufactured from a patient’s own biomaterials—both cells and the supporting scaffolding materials in which cells would be embedded and allowed to mature to eventually regenerate the organ in question. While some groups are focusing on the feasibility of this approach, few are focusing on the immunogenicity of the scaffolds that are being developed for organ bioengineering purposes. This review will succinctly discuss progress in the understanding of immunological characteristics and behavior of different scaffolds currently under development, with emphasis on the extracellular matrix scaffolds obtained decellularized animal or human organs which seem to provide the ideal template for bioengineering purposes. </p>

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Author and article information

Journal

Title: Transplant International

Abbreviated Title: Transpl Int

Publisher: Wiley

ISSN: 09340874

Publication date Created: December 2017

Publication date (Print): December 2017

Publication date (Electronic): October 05 2017

Volume: 30

Issue: 12

Pages: 1199-1208

Affiliations

[1 ]Department of Medicine; Translational Transplant Research Center; Icahn School of Medicine at Mount Sinai; New York NY USA

[2 ]Department of Experimental, Diagnostic, Specialty Medicine, Nephrology, Dialysis, and Renal Transplant Unit; S. Orsola University Hospital; Bologna Italy

[3 ]Wake Forest University School of Medicine; Winston Salem NC USA

[4 ]Section of Transplantation; Department of Surgery; Wake Forest University School of Medicine; Winston Salem NC USA

[5 ]Pôle de Chirurgie Expérimentale (CHEX); Institut de Recherche Expérimentale et Clinique (IREC); Université catholique de Louvain; Brussels Belgium

[6 ]Department of Plastic and Reconstructive Surgery; Cliniques Universitaires St-Luc; Université Catholique de Louvain; Brussels Belgium

[7 ]Division of Urology; GOFARR Laboratory for Organ Regenerative Research and Cell Therapeutics; Saban Research Institute; Children's Hospital Los Angeles; University of Southern California; Los Angeles CA USA