Lucia Lopez-Anglada:
ORCID: http://orcid.org/0000-0003-1727-8546
Role: ConceptualizationRole: Data curationRole: Writing – original draftRole: Writing
– review & editing
Cecilia Cueto-Felgueroso: Role: Data curationRole: InvestigationRole: Methodology
Laura Rosiñol: Role: Data curationRole: SupervisionRole: Writing – review & editing
Albert Oriol: Role: Writing – review & editing
Ana Isabel Teruel: Role: Data curation
Ana Lopez de la Guia: Role: Data curation
Enrique Bengoechea: Role: Data curation
Luis Palomera: Role: Data curation
Felipe de Arriba: Role: Data curation
Jose Mariano Hernandez: Role: Data curation
Miquel Granell: Role: Data curation
Francisco Javier Peñalver: Role: Data curation
Ramon Garcia-Sanz: Role: Data curationRole: Supervision
Juan Besalduch: Role: Data curation
Yolanda Gonzalez: Role: Data curation
Rafael Benigno Martinez: Role: Data curation
Miguel Teodoro Hernandez: Role: Data curation
Norma C. Gutierrez: Role: Data curation
Paloma Puerta: Role: Data curationRole: Methodology
Antonio Valeri: Role: Data curation
Bruno Paiva: Role: Data curationRole: Supervision
Joan Blade: Role: Funding acquisitionRole: SupervisionRole: Writing – review & editing
Maria-Victoria Mateos: Role: ValidationRole: Writing – review & editing
Jesus San Miguel: Role: SupervisionRole: Writing – review & editing
Juan Jose Lahuerta: Role: ConceptualizationRole: Funding acquisitionRole: SupervisionRole: ValidationRole:
Writing – original draftRole: Writing – review & editing
Joaquin Martinez-Lopez: Role: ConceptualizationRole: Funding acquisitionRole: SupervisionRole: ValidationRole:
Writing – original draftRole: Writing – review & editing
Jianjun Zhao: Role: Editor
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
7
September
2018
Publication date Collection: 2018
Volume: 13
Issue: 9
Electronic Location Identifier: e0203392
Affiliations
[1
]
Hematology Department, Hospital Universitario 12 de Octubre, CIBERONC, Madrid, Spain
[2
]
Clinical Biochemistry Department, Hospital Universitario 12 de Octubre, Madrid, Spain
[3
]
Hematology Department, Hospital Clinic, Institut d'Investigacions Biomédiques August
Pi I Sunyer (IDIBAPS), Barcelona, Spain
[4
]
Hospital Germans i Trials, Barcelona, Spain
[5
]
Hematology Department, Hospital Clínico de Valencia, Valencia, Spain
[6
]
Hematology Department, Hospital La Paz, Madrid, Spain
[7
]
Hematology Department, Hospital de Donostia, San Sebastian, Spain
[8
]
Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain
[9
]
Hospital Morales Meseguer, Murcia, Spain
[10
]
Hematology Department, Hospital General de Segovia, Segovia, Spain
[11
]
Haematology, Hospital Univarsitari de la Santa Creu i Sant Pau, Barcelona,Spain
[12
]
Haematology Department, Hospital Universitario Fundacion Alcorcon, Madrid, Spain
[13
]
Hematology Department, Hospital Universitario de Salamanca-IBSAL, IBMCC-CSIC, Salamanca,
Spain
[14
]
Haematology Department, Hospital Univarsitari Son Espases, Mallorca, Spain
[15
]
Haematology Department, Institutd’Oncologia Dr Josep Trueta de Girona, Girona, Spain
[16
]
Haematology Department, Hospital Universitario San Carlos, Madrid, Spain
[17
]
Haematology Department, Hospital Universitario de Canarias, Tenerife, Spain
[18
]
Haematology Department, Clínica Universitaria de Navarra/ CIMA,IDISNA, CIBERONC,Pamplona,
SPAIN
Cleveland Clinic, UNITED STATES
Author notes
Competing Interests: The authors have declared that no competing interests exist.
‡ These authors are joint co-chairs on this study.
¶ Membership of the GEM (Grupo Español de MM)/PETHEMA (Programa para el Estudio de
la Terapéutica en Hemopatías Malignas) Cooperative Study Group^ is provided in the
Acknowledgments.
Author information
Article
Publisher ID:
PONE-D-18-14575
DOI: 10.1371/journal.pone.0203392
PMC ID: 6128544
PubMed ID: 30192814
SO-VID: 42a81510-a3d3-4304-9100-0fb5c317794f
Copyright © © 2018 Lopez-Anglada et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
This research project was supported by grants PI06339, PS09/01370, and PI12/01761
awarded to Sara Borrell (CD13/00340) and Juan Rodes (JR14/00016) from the Fondo de
Investigación Sanitaria (FIS), the Red Temática de Investigación Cooperativa en Cáncer
(RTICC) of the Instituto de Salud Carlos III (Ministry of Economy, Industry, and Competitiveness,
Madrid, Spain), FEDER (RD12/0036/0061, RD12/0036/0048m and RD12/0036/0058) from FIS,
the Asociación Española Contra el Cáncer (AECC; GCB120981SAN), and the CRIS Foundation.
Subject:
Research Article
Subject:
Medicine and Health Sciences
Subject:
Oncology
Subject:
Cancers and Neoplasms
Subject:
Hematologic Cancers and Related Disorders
Subject:
Myelomas and Lymphoproliferative Diseases
Subject:
Myelomas
Subject:
Multiple Myeloma
Subject:
Medicine and Health Sciences
Subject:
Hematology
Subject:
Hematologic Cancers and Related Disorders
Subject:
Myelomas and Lymphoproliferative Diseases
Subject:
Myelomas
Subject:
Multiple Myeloma
Subject:
Medicine and Health Sciences
Subject:
Hematology
Subject:
Plasma Cell Disorders
Subject:
Multiple Myeloma
Subject:
Medicine and Health Sciences
Subject:
Diagnostic Medicine
Subject:
Prognosis
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
Serum Proteins
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Immune Physiology
Subject:
Antibodies
Subject:
Medicine and Health Sciences
Subject:
Physiology
Subject:
Immune Physiology
Subject:
Antibodies
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune System Proteins
Subject:
Antibodies
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune System Proteins
Subject:
Antibodies
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
Immune System Proteins
Subject:
Antibodies
Subject:
Medicine and health sciences
Subject:
Clinical medicine
Subject:
Clinical trials
Subject:
Phase III clinical investigation
Subject:
Medicine and health sciences
Subject:
Pharmacology
Subject:
Drug research and development
Subject:
Clinical trials
Subject:
Phase III clinical investigation
Subject:
Research and analysis methods
Subject:
Clinical trials
Subject:
Phase III clinical investigation
Subject:
Research and Analysis Methods
Subject:
Chemical Characterization
Subject:
Binding Analysis
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune Suppression
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune Suppression
Subject:
Medicine and Health Sciences
Subject:
Diagnostic Medicine
Subject:
Signs and Symptoms
Subject:
Immune Suppression
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Signs and Symptoms
Subject:
Immune Suppression
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Immune Physiology
Subject:
Complement System
Subject:
Medicine and Health Sciences
Subject:
Physiology
Subject:
Immune Physiology
Subject:
Complement System
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune System
Subject:
Complement System
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune System
Subject:
Complement System
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune System Proteins
Subject:
Complement System
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune System Proteins
Subject:
Complement System
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
Immune System Proteins
Subject:
Complement System
