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Levels of interleukin-18 and its binding inhibitors in the blood circulation of patients with adult-onset Still's disease.
M Kawashima
1 ,
M Yamamura ,
M Taniai ,
H Yamauchi ,
T Tanimoto ,
M Kurimoto ,
S Miyawaki ,
T Amano ,
T Takeuchi ,
H Makino
Mar 2001
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Abstract
Interleukin-18 (IL-18) is a proinflammatory cytokine that is involved in immunologically mediated tissue damage, but its bioactivity is regulated in vivo by its soluble decoy receptor, IL-18 binding protein (IL-18BP). This study was undertaken to determine levels of IL-18 and IL-18 binding inhibition in the blood of patients with adult-onset Still's disease (ASD).