Spouse Caregivers’ Experiences of Suffering in Relation to Care for a Partner With Brain Tumor :  A Qualitative Study

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Abstract

Spouses often undertake the main caring role for a partner with primary malignant brain tumor (PMBT). Yet, demanding and challenging caring responsibilities especially because of the partner's cognitive declines can affect the spouse caregiver's well-being.

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Most cited references 38

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Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma

Roger Stupp, Warren P Mason, Martin J van den Bent … (2005)

Glioblastoma, the most common primary brain tumor in adults, is usually rapidly fatal. The current standard of care for newly diagnosed glioblastoma is surgical resection to the extent feasible, followed by adjuvant radiotherapy. In this trial we compared radiotherapy alone with radiotherapy plus temozolomide, given concomitantly with and after radiotherapy, in terms of efficacy and safety. Patients with newly diagnosed, histologically confirmed glioblastoma were randomly assigned to receive radiotherapy alone (fractionated focal irradiation in daily fractions of 2 Gy given 5 days per week for 6 weeks, for a total of 60 Gy) or radiotherapy plus continuous daily temozolomide (75 mg per square meter of body-surface area per day, 7 days per week from the first to the last day of radiotherapy), followed by six cycles of adjuvant temozolomide (150 to 200 mg per square meter for 5 days during each 28-day cycle). The primary end point was overall survival. A total of 573 patients from 85 centers underwent randomization. The median age was 56 years, and 84 percent of patients had undergone debulking surgery. At a median follow-up of 28 months, the median survival was 14.6 months with radiotherapy plus temozolomide and 12.1 months with radiotherapy alone. The unadjusted hazard ratio for death in the radiotherapy-plus-temozolomide group was 0.63 (95 percent confidence interval, 0.52 to 0.75; P<0.001 by the log-rank test). The two-year survival rate was 26.5 percent with radiotherapy plus temozolomide and 10.4 percent with radiotherapy alone. Concomitant treatment with radiotherapy plus temozolomide resulted in grade 3 or 4 hematologic toxic effects in 7 percent of patients. The addition of temozolomide to radiotherapy for newly diagnosed glioblastoma resulted in a clinically meaningful and statistically significant survival benefit with minimal additional toxicity. Copyright 2005 Massachusetts Medical Society.

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Spouses' experience of caregiving for cancer patients: a literature review.

Q Li, Jeffrey Y W Mak, A Loke (2013)

The spouse is generally the primary informal caregiver for cancer patients. Many studies have explored the experience of caregiving for cancer patients, but it is unclear whether there are gender differences in the spousal caring experience for cancer patients.

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The impact of a high-grade glioma on everyday life: a systematic review from the patient's and caregiver's perspective.

Wendy Sterckx, Annemarie Coolbrandt, Bernadette Dierckx de Casterlé … (2013)

With poor prognosis and disabling symptomatology high-grade gliomas affect not only the patient but also the family.

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Author and article information

Journal

Title: Cancer Nursing

Abbreviated Title: Cancer Nurs

Publisher: Ovid Technologies (Wolters Kluwer Health)

ISSN (Electronic): 1538-9804

ISSN (Print): 0162-220X

Publication date Created: 2022

Publication date (Print): March 2022

Publication date (Electronic): February 27 2021

Volume: 45

Issue: 2

Pages: E320-E328

Article

DOI: 10.1097/NCC.0000000000000935

PubMed ID: 33654012

SO-VID: 42351af7-bc40-4aca-9115-188ffbaacd9e

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Spouse Caregivers’ Experiences of Suffering in Relation to Care for a Partner With Brain Tumor : A Qualitative Study

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Special feature: Methodological Innovations in Qualitative Educational Research

Most cited references 38

Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma

Spouses' experience of caregiving for cancer patients: a literature review.

The impact of a high-grade glioma on everyday life: a systematic review from the patient's and caregiver's perspective.

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