Ultrasound molecular imaging of acute cellular cardiac allograft rejection in rat with T-cell-specific nanobubbles.

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Abstract

Acute rejection (AR) is one of the main obstacles of cardiac transplantation; however, a noninvasive diagnostic method, which reflects its pathologic nature, has not been developed yet. In this study, we prepared a specific nanobubbles targeting to the activated T cells and applied it in the ultrasound molecular imaging of AR in heart transplantation by myocardial contrast echocardiography (MCE).

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Journal

Journal ID (iso-abbrev): Transplantation

Title: Transplantation

Publisher: Ovid Technologies (Wolters Kluwer Health)

ISSN (Electronic): 1534-6080

ISSN (Print): 0041-1337

Publication date (Electronic): Sep 2013

Volume: 96

Issue: 6

Affiliations

[1 ] 1 Department of Cardio-Thoracic Surgery, Southwest Hospital, Third Military University, Shapingba, Chongqing, China. 2 Department of Cardiac Surgery, Third Hospital, Peking University, Haidian District, Beijing, China. 3 Department of Ultrasound, Xinqiao Hospital, Third Military University, Shapingba, Chongqing, China. 4 Department of Ultrasound, Southwest Hospital, Third Military University, Shapingba, Chongqing, China. 5 Address correspondence to: Xing Hua, M.D., Department of Ultrasound, Southwest Hospital, Third Military University, Shapingba, Chongqing 400038, P.R. China.

Article

DOI: 10.1097/TP.0b013e31829b759f

PubMed ID: 23921443

SO-VID: 4165277e-1eb5-46cb-b8d7-6b9cd0eaaada

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