LincRNA-p21 regulates neointima formation, vascular smooth muscle cell proliferation, apoptosis, and atherosclerosis by enhancing p53 activity.

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Abstract

Long noncoding RNAs (lncRNAs) have recently been implicated in many biological processes and diseases. Atherosclerosis is a major risk factor for cardiovascular disease. However, the functional role of lncRNAs in atherosclerosis is largely unknown.

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Journal ID (iso-abbrev): Circulation

Title: Circulation

Publisher: Ovid Technologies (Wolters Kluwer Health)

ISSN (Electronic): 1524-4539

ISSN (Print): 0009-7322

Publication date (Electronic): Oct 21 2014

Volume: 130

Issue: 17

Affiliations

[1 ] From the Department of Cardiology, Chongqing Institute of Cardiology, Daping Hospital (G.W., J. Cai, Y.H., C.C., Y.C., H.H., Y.Y., Y.L., Z.X., D.H., X.Z., C.Z.) and Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences (D.Z., F.H.), Third Military Medical University, Chongqing, China; Department of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, MA (G.W., J. Chen, Z.-P.H., X.H., D.-Z.W.); Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Harvard School of Public Heath, Boston, MA (L.P., G.-C.H.); and Harvard Stem Cell Institute, Harvard University, Cambridge, MA (D.-Z.W.).

[2 ] From the Department of Cardiology, Chongqing Institute of Cardiology, Daping Hospital (G.W., J. Cai, Y.H., C.C., Y.C., H.H., Y.Y., Y.L., Z.X., D.H., X.Z., C.Z.) and Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences (D.Z., F.H.), Third Military Medical University, Chongqing, China; Department of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, MA (G.W., J. Chen, Z.-P.H., X.H., D.-Z.W.); Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Harvard School of Public Heath, Boston, MA (L.P., G.-C.H.); and Harvard Stem Cell Institute, Harvard University, Cambridge, MA (D.-Z.W.). dwang@enders.tch.harvard.edu chunyuzeng01@163.com.

Article

Publisher Item ID: CIRCULATIONAHA.114.011675 Mid ID: NIHMS622894

DOI: 10.1161/CIRCULATIONAHA.114.011675

PMC ID: 4244705

PubMed ID: 25156994

SO-VID: 41053b16-f855-4ab8-aedf-f87095609500

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Keywords: MDM2 protein,RNA, long noncoding,apoptosis,atherosclerosis,cell proliferation,tumor suppressor protein p53

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Keywords: MDM2 protein, RNA, long noncoding, apoptosis, atherosclerosis, cell proliferation, tumor suppressor protein p53

LincRNA-p21 regulates neointima formation, vascular smooth muscle cell proliferation, apoptosis, and atherosclerosis by enhancing p53 activity.

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