Synthesis of Dihydropyridinone-Fused Indoles and α-Carbolines via N-Heterocyclic Carbene-Catalyzed [3 + 3] Annulation of Indolin-2-imines and Bromoenals.

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

The N-heterocyclic carbene catalyzed [3 + 3] annulation of indolin-2-imines and bromoenals was developed to give dihydropyridinone-fused indoles in good to high yields, which were transformed to α-carbolines with different 2-subsituents by a process of dehydrogenation, tosylation, and palladium catalyzed C-C or C-N coupling reaction.

Related collections

Author and article information

Journal

Journal ID (iso-abbrev): Org. Lett.

Title: Organic letters

Publisher: American Chemical Society (ACS)

ISSN (Electronic): 1523-7052

ISSN (Print): 1523-7052

Publication date (Electronic): May 05 2017

Volume: 19

Issue: 9

Affiliations

[1 ] Beijing National Laboratory for Molecular Science, Key Laboratory of Molecular Recognition and Function, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, China.

[2 ] Marine College, Shandong University at Weihai , 180 Wenhua West Road, Weihai 264209, China.

[3 ] University of Chinese Academy of Science , Beijing 100049, P. R. China.

Article

DOI: 10.1021/acs.orglett.7b00820

PubMed ID: 28430455

SO-VID: 40fa1622-67fc-4931-8115-d1e2ffbc4f48

History

Data availability:

Comments

Comment on this article

scite_

Cited by 6

See all cited by