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Clinical Probe of Cyp2C8*2 Mutants in a Malaria Hyperendemic Zone: Evidence from North-Central, Nigeria.
Olalere Shittu
1 ,
Olufunke Adenike Opeyemi
2 ,
Olumuyiwa Babagbemi Omotesho
3 ,
Oluwatosin Fakayode
4 ,
Nnaemeka Asogwa
5 ,
Opeyemi Margaret Adeniyi
2 ,
Ifeoluwa Margaret Fatoba
2 ,
Kayode Muritala Salawu
6 ,
Olusola Ajibaye
7 ,
Olarewaju Abdulkareem Babamale
2 ,
Oluyinka Ajibola Iyiola
8 ,
Olusola Isaac Aremu
9
2020
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Abstract
A tremendous level of success has been achieved since the introduction of chloroquine and the combination of amodiaquine and artemisinin for the treatment of both complicated and uncomplicated malaria infections in sub-Saharan Africa. However, the recent discovery of drug resistant strains of Plasmodium falciparum (P.f.) and the ability of the parasite to ingest CYP2C8 into its digestive vacuole is of great public health concern. This study probes the occurrence of CYP2C8*2 allelic mutant amongst malaria patients in North-Central Nigeria.