For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
11
views
32
references
 Top references
cited by
7
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      122
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Inflammation-Immunity-Nutrition Score: A Novel Prognostic Score for Patients with Resectable Colorectal Cancer

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Purpose

          This study was designed to investigate the prognostic value of the combination of high-sensitivity C-reactive protein, lymphocyte, and albumin in patients with resectable colorectal cancer.

          Patients and Methods

          Seven-hundred-and-nineteen patients who underwent colorectal cancer resection in Hubei Cancer Hospital were included. Inflammation-Immunity-Nutrition score (0–6) was constructed based on preoperative high-sensitivity C-reactive protein, lymphocyte, and albumin. Time-dependent receiver operating characteristic curve, decision curve, Kaplan-Meier survival curve, Cox regression, and C-index were conducted to detect the prognostic values of inflammation-immunity-nutrition score. The prognostic values of inflammation-immunity-nutrition score in different subgroups by sex, location of tumor, pathologic stage, and KRAS mutation were also explored. The prognostic performance of inflammation-immunity-nutrition score was further compared with that of other traditional prognostic indicators.

          Results

          The median follow-up time was 40 months. High inflammation-immunity-nutrition score (>2 scores) presented worse survival, with the adjusted hazard ratios (95% confidence intervals) of 3.106 (2.202–4.380) for overall survival and 2.105 (1.604–2.764) for disease-free survival. Besides, the associations of high inflammation-immunity-nutrition score with overall survival were even stronger in cases with wild type KRAS, with the adjusted hazard ratios (95% confidence intervals) of 4.018 (2.355–6.854). Considering the AUCs, C-indices, and hazard ratios estimates, inflammation-immunity-nutrition score presented better prognostic performance than high-sensitivity modified Glasgow prognostic score, high-sensitivity C-reactive protein to albumin ratio, prognostic nutrition index, carcinoembryonic antigen, and carbohydrate antigen 19-9 for overall survival.

          Conclusion

          Inflammation-immunity-nutrition score might serve as a powerful prognostic score in patients with colorectal cancer for overall survival, particularly in patients with wild type KRAS.

          Related collections

          Most cited references32

          • Record: found
          • Abstract: found
          • Article: not found

          Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

          Hyuna Sung, Jacques Ferlay, Rebecca Siegel … (2021)
          This article provides an update on the global cancer burden using the GLOBOCAN 2020 estimates of cancer incidence and mortality produced by the International Agency for Research on Cancer. Worldwide, an estimated 19.3 million new cancer cases (18.1 million excluding nonmelanoma skin cancer) and almost 10.0 million cancer deaths (9.9 million excluding nonmelanoma skin cancer) occurred in 2020. Female breast cancer has surpassed lung cancer as the most commonly diagnosed cancer, with an estimated 2.3 million new cases (11.7%), followed by lung (11.4%), colorectal (10.0 %), prostate (7.3%), and stomach (5.6%) cancers. Lung cancer remained the leading cause of cancer death, with an estimated 1.8 million deaths (18%), followed by colorectal (9.4%), liver (8.3%), stomach (7.7%), and female breast (6.9%) cancers. Overall incidence was from 2-fold to 3-fold higher in transitioned versus transitioning countries for both sexes, whereas mortality varied <2-fold for men and little for women. Death rates for female breast and cervical cancers, however, were considerably higher in transitioning versus transitioned countries (15.0 vs 12.8 per 100,000 and 12.4 vs 5.2 per 100,000, respectively). The global cancer burden is expected to be 28.4 million cases in 2040, a 47% rise from 2020, with a larger increase in transitioning (64% to 95%) versus transitioned (32% to 56%) countries due to demographic changes, although this may be further exacerbated by increasing risk factors associated with globalization and a growing economy. Efforts to build a sustainable infrastructure for the dissemination of cancer prevention measures and provision of cancer care in transitioning countries is critical for global cancer control.
          Article 0 comments Cited 36121 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            X-tile: a new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization.

            Robert Camp, Marisa Dolled-Filhart, David Rimm (2004)
            The ability to parse tumors into subsets based on biomarker expression has many clinical applications; however, there is no global way to visualize the best cut-points for creating such divisions. We have developed a graphical method, the X-tile plot that illustrates the presence of substantial tumor subpopulations and shows the robustness of the relationship between a biomarker and outcome by construction of a two dimensional projection of every possible subpopulation. We validate X-tile plots by examining the expression of several established prognostic markers (human epidermal growth factor receptor-2, estrogen receptor, p53 expression, patient age, tumor size, and node number) in cohorts of breast cancer patients and show how X-tile plots of each marker predict population subsets rooted in the known biology of their expression.
            Article 0 comments Cited 1198 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: not found
              • Article: not found

              Markers of Inflammation and Cardiovascular Disease: Application to Clinical and Public Health Practice: A Statement for Healthcare Professionals From the Centers for Disease Control and Prevention and the American Heart Association

              Thomas A Pearson, George Mensah, R Alexander … (2003)
              Article 0 comments Cited 572 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): J Inflamm Res
                Journal ID (iso-abbrev): J Inflamm Res
                Journal ID (publisher-id): jir
                Journal ID (pmc): jinres
                Title: Journal of Inflammation Research
                Publisher: Dove
                ISSN (Electronic): 1178-7031
                Publication date (Electronic): 10 September 2021
                Publication date Collection: 2021
                Volume: 14
                Pages: 4577-4588
                Affiliations
                [1 ]Department of Epidemiology and Biostatistics, The Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Huazhong University of Science and Technology , Wuhan, People’s Republic of China
                [2 ]Department of Gastrointestinal Oncology Surgery, Hubei Cancer Hospital, The Seventh Clinical School Affiliated of Tongji Medical College, Huazhong University of Science and Technology , Wuhan, People’s Republic of China
                [3 ]Department of Abdominal Oncology, Hubei Cancer Hospital, The Seventh Clinical School Affiliated of Tongji Medical College, Huazhong University of Science and Technology , Wuhan, People’s Republic of China
                Author notes
                Correspondence: Li Liu Department of Epidemiology and Biostatistics, the Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Huazhong University of Science and Technology , Wuhan, People’s Republic of ChinaTel/Fax +86-27-83693763 Email liul2012@hust.edu.cn
                Xin-Jun Liang Department of Abdominal Oncology, Hubei Cancer Hospital, The Seventh Clinical School Affiliated of Tongji Medical College, Huazhong University of Science and Technology , Wuhan, People’s Republic of ChinaTel/Fax +86-27-87671663 Email doctorlxj@163.com
                Author information
                http://orcid.org/0000-0002-5180-7926
                Article
                Publisher ID: 322260
                DOI: 10.2147/JIR.S322260
                PMC ID: 8439969
                SO-VID: 40a90a33-e6dc-4ff4-97f2-9082c5938f6f
                Copyright © © 2021 Li et al.
                License:

                This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License ( http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms ( https://www.dovepress.com/terms.php).

                History
                Date received : 28 May 2021
                Date accepted : 17 August 2021
                Page count
                Figures: 4, Tables: 9, References: 32, Pages: 12
                Funding
                Funded by: National Natural Science Foundation of China to Shao-Fa Nie;
                Funded by: the National Natural Science Foundation of China to Li Liu;
                Funded by: Health commission of Hubei Province scientific research project to Li Liu;
                Funded by: Hubei Provincial Natural Science Foundation to Xin-Jun Liang;
                Funded by: Foundation of Chinese Society of Clinical Oncology to Xin-Jun Liang;
                Funded by: National Key R&D Program of China to Xin-Jun Liang;
                Funded by: Health commission of Hubei Province scientific research project to Xin-Jun Liang;
                Funded by: National Key R&D Program of China to Shao-Zhong Wei;
                Funded by: Health commission of Hubei Province scientific research project to Shao-Zhong Wei;
                Funded by: Hubei Provincial Natural Science Foundation to Shao-Zhong Wei;
                This work was supported by the National Natural Science Foundation of China to Shao-Fa Nie (Grant No. 81974491), the National Natural Science Foundation of China to Li Liu (Grant No. 81302491 and No. 82173602), the Health commission of Hubei Province scientific research project to Li Liu (Grant No. WJ2019Q027), the Applied Basic Research Program of Wuhan Science and Technology Bureau to Xin-Jun Liang (Grant No. 2020020601012250), the Foundation of Chinese Society of Clinical Oncology to Xin-Jun Liang (Grant No. CSCO: Y-HS2019-39 and No. CSCO: Y-QL2019-0351), the Health commission of Hubei Province scientific research project to Xin-Jun Liang (Grant No. WJ2021Z001), the National Key R&D Program of China to Shao-Zhong Wei (Grant No. 2017YFC0908200), the Health commission of Hubei Province scientific research project to Shao-Zhong Wei (Grant No. WJ2019H121), and the Hubei Provincial Natural Science Foundation to Shao-Zhong Wei (Grant No. 2019ACA135).
                Categories
                Subject: Original Research

                ScienceOpen disciplines: Immunology
                Keywords: high-sensitivity c-reactive protein,survival,colorectal cancer,inflammation
                Data availability:
                ScienceOpen disciplines: Immunology
                Keywords: high-sensitivity c-reactive protein, survival, colorectal cancer, inflammation

                Comments

                Comment on this article

                scite_

                Similar content122

                See all similar

                Cited by7

                See all cited by

                Most referenced authors750

                See all reference authors