For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
8
views
25
references
 Top references
cited by
9
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      548
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Sudden sensorineural hearing loss: What factors influence the response to therapy?

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The standard treatment of Sudden Sensorineural Hearing Loss is based on oral steroids. In addition, intratympanic steroid is currently used in patients who fail to respond to oral treatment. The aim of the present study was to evaluate, in patients affected by SSHL, factors that influence the response to systemic and intratympanic steroid treatment. A retrospective analysis was conducted on 149 patients, all treated with systemic steroids. Moreover, patients not responsive to systemic therapy were treated with intratympanic steroids as salvage therapy. Auditory gain was assessed through the recovery rate at the discharge and after 30 days. Statistical analysis demonstrated that patients with delayed treatment and down-sloping auditory curve presented a poor recovery. Linear and stepwise regression showed that hypertriglyceridemia and hyperglycemia were negative prognostic factors. The prognosis of SSHL is affected by hyperglycemia and hypertriglyceridemia suggesting that a microvascular dysfunction within the cochlea could impair hearing recovery. Intratympanic steroid treatment was used as salvage treatment, however in patients with poor prognostic factors or at risk for side effects, it could be used in association with systemic treatment.

          Related collections

          Most cited references25

          • Record: found
          • Abstract: found
          • Article: not found

          Sudden hearing loss: eight years' experience and suggested prognostic table.

          F M Byl (1984)
          The etiology, incidence, acute and late prognosis, and treatment of sudden hearing loss (SHL) are described variously in the literature. In an 8-year prospective study of 225 SHL patients, initiated in July 1973, overall, normal, or complete recovery occurred in 45% of patients and late otologic complications in 28%. Important prognostic indicators were severity of initial hearing loss and vertigo, time to initial audiogram, and elevated erythrocyte sedimentation rate; other indicators were age greater than 60 and less than 15 years, midfrequency audiogram configuration, and hearing status of the opposite ear. A common inflammatory cause is suggested for all degrees of severity in SHL, and a prognostic table is provided to aid the practitioner in predicting recovery. There is still no evidence that treatment achieves a result better than expected with spontaneous recovery.
          Article 0 comments Cited 139 times – based on 0 reviews     Review now
          Article has an altmetric score of 9
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Prognostic model for predicting hearing recovery in idiopathic sudden sensorineural hearing loss.

            Rudolf Probst, Stefan Hegemann, Dragoslava Deric … (2008)
            To aid in realistic counseling of patients at the time of their first visit concerning their chances for recovery, we created a simple prognostic model for predicting hearing recovery in idiopathic sudden sensorineural hearing loss (ISSHL). An important element of research on ISSHL is to identify prognostic factors for this disease. Many studies have described predictive indicators to identify patients with a good prognosis needing no or minimal treatment. Only a few of these studies have included a model for calculating the probability for patient recovery, which may be important for clinical work, but these prognostic tables have not achieved widespread use clinically. Evaluation of an electronic patient data base of 541 patients with ISSHL. The standard treatment was carbogen inhalation (95% O2 and 5% CO2 8 times per day in duration of 30 min) and prednisone orally (100 mg in 1 morning dose) for 7 days. Factors that were analyzed included the patient's age, the interval between the onset of symptoms and beginning of treatment, the presence or absence of vertigo and tinnitus, audiometric patterns, the severity of hearing loss, and hearing in the opposite ear. Hearing gain was expressed either as absolute hearing gain or as relative hearing gain. Significant recovery of hearing was defined as the final pure-tone audiometry of 30 dB or less (or the same as the pure-tone audiometry of the opposite ear). The absolute hearing gain was 15.1 dB. The mean relative hearing gain was 47%. Three hundred one (57%) patients had significant recovery of hearing, and 228 (43%) did not have significant recovery of hearing. Using step-wise multiple linear regression analysis, the most important factors for prognosis included severity of hearing loss, presence of vertigo, time between onset and treatment, the hearing of the other ear, and the audiogram shape (beta coefficient was -0.216, -0.231, 0.211, 0.113, and -0.064, respectively; constant, 0.968). A recovery expectancy table was developed using the data from this study. Based on a retrospective analysis, prognostic indicators for hearing recovery in ISSHL were found to be severity of hearing loss, presence of vertigo, time between onset and treatment, the hearing of the other ear, and the audiogram shape. We created a model for calculating the probability for hearing recovery based on the analysis of 529 patients with unilateral ISSHL.
            Article 0 comments Cited 37 times – based on 0 reviews     Review now
            Article has an altmetric score of 6
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Effectiveness of intratympanic dexamethasone injection in sudden-deafness patients as salvage treatment.

              Mong-Hsun Tsai, Min Shu, Pao-Hung Lin … (2004)
              To study the effectiveness of intratympanic dexamethasone (IT-DEX) in patients with severe or profound sudden sensorineural hearing loss (SSNHL) after treatment failure with conventional therapy. Randomized, controlled study. Patients who met the criteria for SSNHL, with a severity of severe to profound, underwent 10 days of standard treatment with oral steroid and other facilitating agents. Patients showing poor response to standard treatment were assigned randomly to a control group or to a group receiving IT-DEX. IT-DEX injections were performed once a week for 3 consecutive weeks. Pure-tone audiometry was obtained before each injection. Minimum follow-up time was 1 month. Successful treatment was defined as a hearing improvement of greater than 30 dB. Thirty-nine patients meeting the inclusion criteria were studied. After treatment with oral steroid, 10 of 39 (26%) patients demonstrated hearing improvement, whereas the remaining 29 (74%) patients showed a hearing improvement of less than 30 dB. For those without hearing improvement, 15 received IT-DEX, and 14 received further standard treatment (except oral steroid and carbogen inhalation). Hearing improved in 8 of 15 (53.3%) compared with 1 of 14 (7.1%), with an average decrease in threshold of 28.4 dB and 13.2 dB for the IT-DEX group and the control group, respectively (P <.05). Prognostic factors such as age, treatment delay time, and sex did not significantly affect the response to therapy. IT-DEX injection effectively improves hearing in patients with severe or profound SSNHL after treatment failure with standard therapy and is not associated with major side effects. It is therefore a reasonable alternative as salvage treatment.
              Article 0 comments Cited 34 times – based on 0 reviews     Review now
              Article has an altmetric score of 9
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): Audiol Res
                Journal ID (publisher-id): AUDIO
                Title: Audiology Research
                Publisher: PAGEPress Publications, Pavia, Italy
                ISSN (Print): 2039-4330
                ISSN (Electronic): 2039-4349
                Publication date (Electronic): 06 August 2020
                Publication date Collection: 07 July 2020
                Volume: 10
                Issue: 1
                Electronic Location Identifier: 234
                Affiliations
                [1 ]Otolaryngology Unit, Department of BMS, Neuroscience and Sensory Organs, University of Bari “Aldo Moro”
                [2 ]Research Unit on Aging “Great Age Study”, National Institute of Gastroenterology and Research Hospital IRCCS “S.DeBellis” , Bari, Italy
                Author notes
                University of Bari, p.zza Giulio Cesare 11-70124 Bari, Italy. irenesciancalepore@ 123456gmail.com +39-080-5478850-3408425067+39-080-5478752

                Conflict of interest: the authors declare no potential conflict of interests.

                Article
                DOI: 10.4081/audiores.2020.234
                PMC ID: 7479339
                PubMed ID: 32944207
                SO-VID: 40702407-da40-4d77-bef0-1f1aae172c19
                Copyright © ©Copyright: the Author(s)
                License:

                This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 14 October 2019
                Date accepted : 12 February 2020
                Page count
                Figures: 1, Tables: 4, Equations: 0, References: 26, Pages: 5
                Categories
                Subject: Article

                Keywords: sudden hearing loss,steroid therapy,intratympanic therapy,hypertriglyceridemia,hyperglycaemia
                Data availability:
                Keywords: sudden hearing loss, steroid therapy, intratympanic therapy, hypertriglyceridemia, hyperglycaemia

                Comments

                Comment on this article

                scite_
                0
                0
                0
                0
                Smart Citations
                0
                0
                0
                0
                Citing PublicationsSupportingMentioningContrasting
                View Citations

                See how this article has been cited at scite.ai

                scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.

                Similar content548

                See all similar

                Cited by9

                See all cited by

                Most referenced authors233

                See all reference authors