- Record: found
- Abstract: not found
- Article: not found
Dual stromal targeting sensitizes pancreatic adenocarcinoma for anti-PD-1 therapy
Alex B. Blair ,
Jianxin Wang ,
John Davelaar ,
Andrew Baker ,
Keyu Li ,
Nan Niu ,
Junke Wang ,
Yingkuan Shao ,
Vanessa Funes ,
Pan Li ,
Jonathan A. Pachter ,
Dan Maneval ,
Felipe Dezem ,
Jasmine Plummer ,
Keith Syson Chan ,
Jun Gong ,
Andrew E. Hendifar ,
Stephen J. Pandol ,
Richard Burkhart ,
Yuqing Zhang ,
Lei Zheng ,
Arsen Osipov
June 2022
June 2022
Read this article at
There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
<p class="first" id="d4585129e307">The stroma in pancreatic ductal adenocarcinoma
(PDAC) contributes to its immunosuppressive
nature and therapeutic resistance. Herein we sought to modify signaling and enhance
immunotherapy efficacy by targeting multiple stromal components through both intracellular
and extracellular mechanisms.
</p>