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      Impacto socio - económico de casos de dengue con signos de alarma y severo, neumonía y meningitis bacteriana aguda, en pacientes pediátricos hospitalizados en un centro de referencia Translated title: Socio-economic impact of severe dengue cases, pneumonia and acute bacterial meningitis in pediatric patients hospitalized in a reference center

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          Abstract

          RESUMEN Introducción: El dengue, la neumonía y la Meningitis Bacteriana Aguda (MBA), producen un elevado impacto socioeconómico, una elevada carga económica y social en los sistemas de salud y la sociedad. Objetivo: comparar el costo económico y la carga por dengue, neumonía y MBA en ≤15 años hospitalizados, entre enero/07 y mayo/19. Materiales y Métodos: Estudio observacional, descriptivo. Los datos fueron obtenidos de expedientes de pacientes hospitalizados con diagnósticos de Dengue, neumonía y MBA. Los costos médicos directos se obtuvieron de la base de datos del IMT. Para los costos directos no médicos y los indirectos se utilizó literatura internacional estimados para Paraguay. Los DALYs fueron calculados a partir de la suma de los AVPP y los DVSP. Resultados: Se identificaron 784, 1419 y 125 pacientes con Dengue, neumonía y MBA, respectivamente. La edad media fue de 118,1±53,6; 34,0±38,9 y 52,1±64,3 meses, respectivamente (p<0.05). La media de días de hospitalización: 4,8±2,8; 9,4±8,7 y 13,8±14,0 días, respectivamente. El 8,9%(70/784) de los casos con dengue, el 29,6%(420/1419) de las neumonías y el 70,4%(88/125) de las MBA requirieron UCI. El 0,6%(5/784), el 5,3%(78/1419) y el 31,2%(39/125) pacientes fallecieron. El costo por hospitalización por dengue, neumonía y meningitis fue de 465496, 3094721 y 127063 US$, respectivamente; los AVPP fueron de 328.1, 5373.4 y 1846.7 años, respectivamente; los DVSP fueron 1459.8, 8595.2 y 996.1, respectivamente y los DALYs de 1641.66; 13968.6 y 2842.8, respectivamente. Conclusiones: Los costos de atención de estas patologías, inmunoprevenibles, son considerables, producen un impacto social importante, en el sector salud y la economía en general del país.

          Translated abstract

          ABSTRACT Introduction: Dengue, pneumonia and Acute Bacterial Meningitis (ABM) produce a high socioeconomic impact, a high economic and social burden on health systems and society. Objective: to compare the economic costs and burdens of dengue, pneumonia and ABM in hospitalized patients ≤15 years of age, between January 2007 and May 2019. Materials and Methods: This was an observational and descriptive study. The data were obtained from records of hospitalized patients diagnosed with Dengue, pneumonia and ABM. Direct medical costs were obtained from the hospital database. For direct non-medical and indirect costs, international literature estimates for Paraguay were used. The DALYs were calculated from the sum of the AVPP and the DVSP. Results: 784, 1419 and 125 patients with Dengue, pneumonia and ABM were identified, respectively. The mean age was 118.1 ± 53.6; 34.0±38.9 and 52.1±64.3 months, respectively (p<0.05). Mean days of hospitalization: 4.8±2.8; 9.4±8.7 and 13.8±14.0 days, respectively. 8.9% (70/784) of the cases with dengue, 29.6% (420/1419) of the pneumonias and 70.4% (88/125) of the ABM cases required ICU. 0.6% (5/784), 5.3% (78/1419) and 31.2% (39/125) patients died. The cost per hospitalization for dengue, pneumonia, and meningitis was US\(465,496, US\) 3094,721, and US$ 127,063, respectively; YPPA were 328.1, 5373.4 and 1846.7 years, respectively; the DVSPs were 1459.8, 8595.2 and 996.1, respectively, and the DALYs were 1641.66; 13968.6 and 2842.8, respectively. Conclusions: The costs of care for these immunopreventable pathologies are considerable, they produce an important impact in the country’s social, health and economic sectors.

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          Global, regional, and national causes of under-5 mortality in 2000–15: an updated systematic analysis with implications for the Sustainable Development Goals

          Summary Background Despite remarkable progress in the improvement of child survival between 1990 and 2015, the Millennium Development Goal (MDG) 4 target of a two-thirds reduction of under-5 mortality rate (U5MR) was not achieved globally. In this paper, we updated our annual estimates of child mortality by cause to 2000–15 to reflect on progress toward the MDG 4 and consider implications for the Sustainable Development Goals (SDG) target for child survival. Methods We increased the estimation input data for causes of deaths by 43% among neonates and 23% among 1–59-month-olds, respectively. We used adequate vital registration (VR) data where available, and modelled cause-specific mortality fractions applying multinomial logistic regressions using adequate VR for low U5MR countries and verbal autopsy data for high U5MR countries. We updated the estimation to use Plasmodium falciparum parasite rate in place of malaria index in the modelling of malaria deaths; to use adjusted empirical estimates instead of modelled estimates for China; and to consider the effects of pneumococcal conjugate vaccine and rotavirus vaccine in the estimation. Findings In 2015, among the 5·9 million under-5 deaths, 2·7 million occurred in the neonatal period. The leading under-5 causes were preterm birth complications (1·055 million [95% uncertainty range (UR) 0·935–1·179]), pneumonia (0·921 million [0·812 −1·117]), and intrapartum-related events (0·691 million [0·598 −0·778]). In the two MDG regions with the most under-5 deaths, the leading cause was pneumonia in sub-Saharan Africa and preterm birth complications in southern Asia. Reductions in mortality rates for pneumonia, diarrhoea, neonatal intrapartum-related events, malaria, and measles were responsible for 61% of the total reduction of 35 per 1000 livebirths in U5MR in 2000–15. Stratified by U5MR, pneumonia was the leading cause in countries with very high U5MR. Preterm birth complications and pneumonia were both important in high, medium high, and medium child mortality countries; whereas congenital abnormalities was the most important cause in countries with low and very low U5MR. Interpretation In the SDG era, countries are advised to prioritise child survival policy and programmes based on their child cause-of-death composition. Continued and enhanced efforts to scale up proven life-saving interventions are needed to achieve the SDG child survival target. Funding Bill & Melinda Gates Foundation, WHO.
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            The global burden of dengue: an analysis from the Global Burden of Disease Study 2013.

            Dengue is the most common arbovirus infection globally, but its burden is poorly quantified. We estimated dengue mortality, incidence, and burden for the Global Burden of Disease Study 2013.
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              Dengue

              Mortality from severe dengue is low, but the economic and resource burden on health services remains substantial in endemic settings. Unfortunately, progress towards development of effective therapeutics has been slow, despite notable advances in the understanding of disease pathogenesis and considerable investment in antiviral drug discovery. For decades antibody-dependent enhancement has been the prevalent model to explain dengue pathogenesis, but it was only recently demonstrated in vivo and in clinical studies. At present, the current mainstay of management for most symptomatic dengue patients remains careful observation and prompt but judicious use of intravenous hydration therapy for those with substantial vascular leakage. Various new promising technologies for diagnosis of dengue are currently in the pipeline. New sample-in, answer-out nucleic acid amplification technologies for point-of-care use are being developed to improve performance over current technologies, with the potential to test for multiple pathogens using a single specimen. The search for biomarkers that reliably predict development of severe dengue among symptomatic individuals is also a major focus of current research efforts. The first dengue vaccine was licensed in 2015 but its performance depends on serostatus. There is an urgent need to identify correlates of both vaccine protection and disease enhancement. A crucial assessment of vector control tools should guide a research agenda for determining the most effective interventions, and how to best combine state-of-the-art vector control with vaccination.
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                Author and article information

                Journal
                ped
                Pediatría (Asunción)
                Pediatr. (Asunción)
                Sociedad Paraguaya de Pediatría (Asunción, , Paraguay )
                1683-9803
                December 2022
                : 49
                : 3
                : 172-180
                Affiliations
                [1] Asunción orgnameInstituto de Medicina Tropical Paraguay
                [2] San Lorenzo Asunción orgnameUniversidad Nacional de Asunción orgdiv1Facultad de Ciencias Médicas Paraguay
                Article
                S1683-98032022000300172 S1683-9803(22)04900300172
                10.31698/ped.49032022006
                3fcecf75-7a54-4a8c-ae70-907b450802c3

                This work is licensed under a Creative Commons Attribution 4.0 International License.

                History
                : 10 December 2022
                : 08 November 2022
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 24, Pages: 9
                Product

                SciELO Paraguay

                Categories
                Artículos Originales

                pneumonia, meningitis, cost analysis,Dengue,neumonía, meningitis, análisis de costos

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