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      Identificación de Hantavirus Andes en Rattus norvegicus Translated title: Identification of Andes Hantavirus in Rattus norvegicus

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          Abstract

          En Chile y Argentina la especie Oligoryzomys longicaudatus ha sido identificada como el principal reservorio para Virus Andes (ANDV). El objetivo de este trabajo es reportar la presencia del virus Andes en Rattus norvergicus, roedor urbano recolectado de un muestreo en San Diego del Cristo, comuna de Melipilla, Región Metropolitana. La presencia del virus Andes en Rattus norvegicus podría indicar la importancia de otros roedores como eventuales vectores virales.

          Translated abstract

          In Chile and Argentina Oligoryzomys longicaudatus has been identified as the main reservoir for Hantavirus Andes. The aim of this work was to report the presence of Hantavirus Andes in Rattus norvegicus, an urban rodent collected during sampling in San Diego del Cristo, Melipilla, Metropolitan Region. The existence of Hantavirus Andes in Rattus norvegicus could indicate the importance of other rodents as possible viral vectors.

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          Genetic diversity, distribution, and serological features of hantavirus infection in five countries in South America.

          J Riquelme, R Rabinovich, M. Della Pietra … (2000)
          Since 1995 when the first case of hantavirus pulmonary syndrome (HPS) was reported in Patagonia, there have been more than 400 cases of HPS reported in five countries in South America. The first case of HPS was associated with Andes (AND) virus. In this study, we report on the genetic diversity, geographical distribution, and serological features of hantavirus infection in six countries in South America based on 87 HPS cases from Argentina, Bolivia, Chile, Paraguay, and Uruguay. An early immunoglobulin M (IgM), IgA, and IgG humoral response was observed in almost all HPS cases. The IgM response appears to peak 1 or 2 days after the onset of symptoms. Peak IgG antibody titers occur mostly after the first week. Low IgG titers or the absence of IgG was associated with higher mortality rates. The IgA response peaks around day 15 and then rapidly decreases. The results of phylogenetic analysis based on partial M-fragment G1- and G2-encoding sequences showed that HPS cases from the five countries were infected with viruses related to AND or Laguna Negra (LN) virus. Within AND virus-infected persons, at least five major genetic lineages were found; one lineage was detected in Uruguayan and Argentinean cases from both sides of the Rio de la Plata river. Two Paraguayan patients were infected with a virus different from LN virus. According to the results of phylogenetic analyses, this virus probably belongs to a distinct lineage related more closely to the AND virus than to the LN virus, suggesting that there is probably an Oligoryzomys-borne viral variant circulating in Paraguay. These studies may contribute to a better understanding of hantavirus human infection in South America.
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            Virus evolution and genetic diversity of hantaviruses and their rodent hosts.

            A Plyusnin, S Morzunov (2001)
            Article 0 comments Cited 51 times – based on 0 reviews     Review now
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              DNA vaccination with hantavirus M segment elicits neutralizing antibodies and protects against seoul virus infection.

              C Schmaljohn, Pamela Hooper, F Elgh … (1999)
              Seoul virus (SEOV) is one of four known hantaviruses causing hemorrhagic fever with renal syndrome (HFRS). Candidate naked DNA vaccines for HFRS were constructed by subcloning cDNA representing the medium (M; encoding the G1 and G2 glycoproteins) or small (S; encoding the nucleocapsid protein) genome segment of SEOV into the DNA expression vector pWRG7077. We vaccinated BALB/c mice with three doses of the M or S DNA vaccine at 4-week intervals by either gene gun inoculation of the epidermis or needle inoculation into the gastrocnemius muscle. Both routes of vaccination resulted in antibody responses as measured by ELISA; however, gene gun inoculation elicited a higher frequency of seroconversion and higher levels of antibodies in individual mice. We vaccinated Syrian hamsters with the M or S construct using the gene gun and found hantavirus-specific antibodies in five of five and four of five hamsters, respectively. Animals vaccinated with the M construct developed a neutralizing antibody response that was greatly enhanced in the presence of guinea pig complement. Immunized hamsters were challenged with SEOV and, after 28 days, were monitored for evidence of infection. Hamsters vaccinated with M were protected from infection, but hamsters vaccinated with S were not protected.
              Article 0 comments Cited 35 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (publisher-id): amv
                Title: Archivos de medicina veterinaria
                Abbreviated Title: Arch. med. vet.
                Publisher: Facultad de Ciencias Veterinarias, Universidad Austral de Chile (Valdivia, , Chile )
                ISSN (Print): 0301-732X
                Publication date (Print and electronic): 2008
                Volume: 40
                Issue: 3
                Pages: 295-298
                Affiliations
                [03] Santiago orgnameUniversidad de Chile orgdiv1Facultad de Ciencias Veterinarias Chile
                [04] Santiago orgnameInstituto de Salud Pública de Chile orgdiv1Departamento de Laboratorios Biomédicos Nacional y Referencia orgdiv2Sección Genética Molecular Chile jfernand@ 123456ispch.cl
                [01] Santiago orgnameInstituto de Salud Pública de Chile orgdiv1Sección Genética Molecular Chile
                [02] Santiago orgnameInstituto de Salud Pública de Chile orgdiv1Subdepto. de Virología Chile
                Article
                Publisher ID: S0301-732X2008000300011 Publisher ID: S0301-732X(08)04000300011
                SO-VID: 3fb07001-efe5-4cda-b910-3342e156471d
                License:

                This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

                History
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 14, Pages: 4
                Product

                SciELO Chile

                Categories
                Subject: COMUNICACIONES

                Keywords: Hantavirus,rodents,cardiopulmonar syndrome,Andes virus,roedores,síndrome cardiopulmonar,virus Andes
                Data availability:
                Keywords: Hantavirus, rodents, cardiopulmonar syndrome, Andes virus, roedores, síndrome cardiopulmonar, virus Andes

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