Contributors
Muhammad Ali:
ORCID: https://orcid.org/0000-0002-1399-6631
Role: ConceptualizationRole: Formal analysisRole: Writing – original draftRole: Writing
– review & editing
Yun Ju Sung:
ORCID: https://orcid.org/0000-0002-8021-4070
Role: Data curation
Fengxian Wang:
ORCID: https://orcid.org/0000-0002-7677-5406
Role: Data curation
Maria V. Fernández: Role: Data curation
John C. Morris: Role: Funding acquisitionRole: Project administrationRole: Writing – review & editing
Anne M. Fagan: Role: Funding acquisitionRole: Project administrationRole: Writing – review & editing
Kaj Blennow: Role: Project administrationRole: Writing – review & editing
Henrik Zetterberg: Role: Project administrationRole: Writing – review & editing
Amanda Heslegrave:
ORCID: https://orcid.org/0000-0002-7290-6405
Role: Project administrationRole: Writing – review & editing
Per M. Johansson:
ORCID: https://orcid.org/0000-0003-0073-7654
Role: Project administrationRole: Writing – review & editing
Johan Svensson:
ORCID: https://orcid.org/0000-0002-4487-6405
Role: Project administrationRole: Writing – review & editing
Bengt Nellgård: Role: Project administrationRole: Writing – review & editing
Alberto Lleó: Role: Project administrationRole: Writing – review & editing
Daniel Alcolea:
ORCID: https://orcid.org/0000-0002-3819-3245
Role: Project administrationRole: Writing – review & editing
Jordi Clarimon: Role: Project administrationRole: Writing – review & editing
Lorena Rami: Role: Project administrationRole: Writing – review & editing
José Luis Molinuevo: Role: Project administrationRole: Writing – review & editing
Marc Suárez-Calvet: Role: Project administrationRole: Writing – review & editing
Estrella Morenas-Rodríguez: Role: Project administrationRole: Writing – review & editing
Gernot Kleinberger: Role: Project administrationRole: Writing – review & editing
Christian Haass: Role: Project administrationRole: Writing – review & editing
Michael Ewers: Role: Project administrationRole: Writing – review & editing
Johannes Levin: Role: Project administrationRole: Writing – review & editing
Martin R. Farlow: Role: Project administrationRole: Writing – review & editing
Richard J. Perrin:
ORCID: https://orcid.org/0000-0002-3443-7716
Role: Project administrationRole: Writing – review & editing
Carlos Cruchaga:
ORCID: https://orcid.org/0000-0002-0276-2899
Role: ConceptualizationRole: Funding acquisitionRole: SupervisionRole: ValidationRole:
Writing – review & editing
Kensaku Kasuga: Role: Editor
Journal
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS One
Journal ID (publisher-id): plos
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
26
May
2022
Publication date Collection: 2022
Volume: 17
Issue: 5
Electronic Location Identifier: e0267298
Affiliations
[1
]
Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri,
United States of America
[2
]
Neurogenomics and Informatics Center, Washington University School of Medicine, St.
Louis, Missouri, United States of America
[3
]
Department of Neurology, Washington University School of Medicine, St. Louis, Missouri,
United States of America
[4
]
Knight Alzheimer Disease Research Center, Washington University School of Medicine,
St. Louis, Missouri, United States of America
[5
]
Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology,
The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden
[6
]
Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, University
of Gothenburg, Sahlgrenska University Hospital, Mölndal, Sweden
[7
]
Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square,
London, United Kingdom
[8
]
UK Dementia Research Institute at UCL, London, United Kingdom
[9
]
Department of Anesthesiology and Intensive Care Medicine, Sahlgrenska University Hospital,
Mölndal, Sweden
[10
]
Institute of Clinical Sciences, The Sahlgrenska Academy at the University of Gothenburg,
Gothenburg, Sweden
[11
]
Department of Internal Medicine, Institute of Medicine, The Sahlgrenska Academy at
the University of Gothenburg, Göteborg, Sweden
[12
]
Neurology Department, Hospital de Sant Pau, Barcelona, Spain
[13
]
IDIBAPS, Alzheimer´s Disease and Other Cognitive Disorders Unit, Neurology Service,
ICN Hospital Clinic, Barcelona, Spain
[14
]
Alzheimer´s Disease and Other Cognitive Disorders Unit, Neurology Service, ICN Hospital
Clinic i Universitari, Barcelona, Spain
[15
]
BarcelonaBeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain
[16
]
Biomedical Center (BMC), Biochemistry, Ludwig‐Maximilians‐Universität München, Munich,
Germany
[17
]
German Center for Neurodegenerative Diseases (DZNE), Munich, Germany
[18
]
Munich Cluster for Systems Neurology (SyNergy), Munich, Germany
[19
]
Institute for Stroke and Dementia Research, University Hospital, Ludwig-Maximilians-Universität
München, Munich, Germany
[20
]
Department of Neurology, Ludwig-Maximilians-Universität München, Munich, Germany
[21
]
Indiana Alzheimer Disease Research Center, Indiana University School of Medicine,
Indianapolis, Indiana, United States of America
[22
]
Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana,
United States of America
[23
]
Hope Center for Neurological Disorders, Washington University School of Medicine,
St. Louis, Missouri, United States of America
[24
]
Department of Pathology and Immunology, Washington University School of Medicine,
St. Louis, Missouri, United States of America
Niigata University, JAPAN
Author notes
Competing Interests: CC receives research support from: Biogen, EISAI, Alector and GSK. The funders of
the study had no role in the collection, analysis, or interpretation of data; in the
writing of the report; or in the decision to submit the paper for publication. CC
is a member of the advisory board of Vivid genetics, Halia Therapeutics, Circular
Genomics and ADx Healthcare. HZ has served at scientific advisory boards and/or as
a consultant for Abbvie, Alector, Eisai, Denali, Roche, Wave, Samumed, Siemens Healthineers,
Pinteon Therapeutics, Nervgen, AZTherapies, CogRx, and Red Abbey Labs, has given lectures
in symposia sponsored by Cellectricon, Fujirebio, Alzecure and Biogen, and is a co-founder
of Brain Biomarker Solutions in Gothenburg AB (BBS), which is a part of the GU Ventures
Incubator Program. KB has served as a consultant, at advisory boards, or at data monitoring
committees for Abcam, Axon, Biogen, JOMDD/Shimadzu. Julius Clinical, Lilly, MagQu,
Novartis, Prothena, Roche Diagnostics, and Siemens Healthineers, and is a co-founder
of Brain Biomarker Solutions in Gothenburg AB (BBS), which is a part of the GU Ventures
Incubator Program, all unrelated to the work presented in this paper. JL reports speaker
fees from Bayer Vital, Biogen and Roche, consulting fees from Axon Neuroscience and
Biogen, author fees from Thieme medical publishers and W. Kohlhammer GmbH medical
publishers, non-financial support from Abbvie and compensation for duty as part-time
CMO from MODAG, outside the submitted work.
¶ Membership of the Alzheimer’s Disease Neuroimaging Initiative (ADNI) and Dominantly
Inherited Alzheimer Network (DIAN) is provided in the Acknowledgments.
Author information
Article
Publisher ID:
PONE-D-22-05551
DOI: 10.1371/journal.pone.0267298
PMC ID: 9135221
PubMed ID: 35617280
SO-VID: 3f78835a-0b1b-4c51-82b0-582fffeda2c4
Copyright © © 2022 Ali et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
History
Date
received
: 23
February
2022
Date
accepted
: 6
April
2022
Page count
Figures: 3,
Tables: 2,
Pages: 16
Funding
Funded by:
funder-id http://dx.doi.org/10.13039/100000957, Alzheimer’s Association;
Award ID: NIRG-11-200110, BAND-14-338165, AARG-16-441560 and BFG-15-362540
Award Recipient
:
ORCID: https://orcid.org/0000-0002-0276-2899
Carlos Cruchaga
Funded by:
funder-id http://dx.doi.org/10.13039/100000009, Foundation for the National Institutes of Health;
Award ID: R01AG044546, P01AG003991, RF1AG053303, R01AG058501, U01AG058922, RF1AG058501 and R01AG057777
Award Recipient
:
ORCID: https://orcid.org/0000-0002-0276-2899
Carlos Cruchaga
Funded by:
funder-id http://dx.doi.org/10.13039/100014761, Hope Center for Neurological Disorders;
Funded by:
the Departments of Neurology and Psychiatry at Washington University School of Medicine
Funded by:
NIH
Award ID: P50 AG05681, P01 AG03991, and P01 AG026276
Funded by:
the Swedish Research Council
Award ID: #2018-02532
Award Recipient
:
Henrik Zetterberg
Funded by:
the European Research Council
Award ID: #681712
Award Recipient
:
Henrik Zetterberg
Funded by:
Swedish State Support for Clinical Research
Award ID: #ALFGBG-720931
Award Recipient
:
Henrik Zetterberg
Funded by:
Alzheimer Drug Discovery Foundation (ADDF), USA
Award ID: 201809-2016862
Award Recipient
:
Henrik Zetterberg
Funded by:
AD Strategic Fund and the Alzheimer’s Association
Award ID: #ADSF-21-831376-C, #ADSF-21-831381-C and #ADSF-21-831377-C
Award Recipient
:
Henrik Zetterberg
Funded by:
Olav Thon Foundation
Award Recipient
:
Henrik Zetterberg
Funded by:
Erling-Persson Family Foundation
Award Recipient
:
Henrik Zetterberg
Funded by:
Stiftelsen för Gamla Tjänarinnor, Hjärnfonden, Sweden
Award Recipient
:
Henrik Zetterberg
Funded by:
European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie
grant agreement
Award ID: 86019
Award Recipient
:
Henrik Zetterberg
Funded by:
UK Dementia Research Institute at UCL
Award Recipient
:
Henrik Zetterberg
Funded by:
Swedish Research Council
Award ID: #2017-00915
Award Recipient
:
Kaj Blennow
Funded by:
the Alzheimer Drug Discovery Foundation (ADDF), USA
Award ID: #RDAPB-201809-2016615
Award Recipient
:
Kaj Blennow
Funded by:
Hjärnfonden, Sweden
Award ID: #FO2017-0243
Award Recipient
:
Kaj Blennow
Funded by:
the Swedish state
Award Recipient
:
Kaj Blennow
Funded by:
the ALF-agreement
Award ID: #ALFGBG-715986
Award Recipient
:
Kaj Blennow
Funded by:
the European Union Joint Program for Neurodegenerative Disorders
Award ID: JPND2019-466-236
Award Recipient
:
Kaj Blennow
Funded by:
the National Institute of Health (NIH), USA
Award ID: #1R01AG068398-01
Award Recipient
:
Kaj Blennow
Funded by:
the Alzheimer’s Association 2021 Zenith Award
Award ID: ZEN-21-848495
Award Recipient
:
Kaj Blennow
This work was supported by grants from the National Institutes of Health (R01AG044546,
P01AG003991, RF1AG053303, R01AG058501, U01AG058922, RF1AG058501 and R01AG057777),
the Alzheimer Association (NIRG-11-200110, BAND-14-338165, AARG-16-441560 and BFG-15-362540).
This work was supported by access to equipment made possible by the Hope Center for
Neurological Disorders, and the Departments of Neurology and Psychiatry at Washington
University School of Medicine. The recruitment and clinical characterization of research
participants at Washington University were supported by NIH P50 AG05681, P01 AG03991,
and P01 AG026276. HZ is a Wallenberg Scholar supported by grants from the Swedish
Research Council (#2018-02532), the European Research Council (#681712), Swedish State
Support for Clinical Research (#ALFGBG-720931), the Alzheimer Drug Discovery Foundation
(ADDF), USA (#201809-2016862), the AD Strategic Fund and the Alzheimer’s Association
(#ADSF-21-831376-C, #ADSF-21-831381-C and #ADSF-21-831377-C), the Olav Thon Foundation,
the Erling-Persson Family Foundation, Stiftelsen för Gamla Tjänarinnor, Hjärnfonden,
Sweden (#FO2019-0228), the European Union’s Horizon 2020 research and innovation programme
under the Marie Skłodowska-Curie grant agreement No 860197 (MIRIADE), and the UK Dementia
Research Institute at UCL. KB is supported by the Swedish Research Council (#2017-00915),
the Alzheimer Drug Discovery Foundation (ADDF), USA (#RDAPB-201809-2016615), the Swedish
Alzheimer Foundation (#AF-742881), Hjärnfonden, Sweden (#FO2017-0243), the Swedish
state under the agreement between the Swedish government and the County Councils,
the ALF-agreement (#ALFGBG-715986), the European Union Joint Program for Neurodegenerative
Disorders (JPND2019-466-236), the National Institute of Health (NIH), USA, (grant
#1R01AG068398-01), and the Alzheimer’s Association 2021 Zenith Award (ZEN-21-848495).
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