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A DNA aptamer which binds to and inhibits thrombin exhibits a new structural motif for DNA
May 2002
May 2002
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Abstract
<p class="first" id="d2893863e77">The investigation of the three-dimensional structure
of the DNA aptamer d(G1G2T3-T4G5G6T7G8T9G10G11T12T13G14G15)
which binds to and inhibits thrombin has been carried out by NMR methods. This DNA
exhibits a number of long-range NOEs between residues which are not adjacent in sequence,
which allowed the determination of the novel tertiary structure adopted. This DNA
adopts a highly compact, highly symmetrical structure which consists of two tetrads
of guanosine base pairs and three loops. The residues of the tetrads alternate anti-syn-anti-syn.
This novel structural motif for DNA may also be relevant to the structure of telomere
DNA.
</p>