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      Mesenchymal stem cell therapy combined with arthroscopic abrasion arthroplasty regenerates cartilage in patients with severe knee osteoarthritis: a case series.

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          Abstract

          Aim: To evaluate the safety and efficacy of adipose-derived mesenchymal stem cell (ADMSC) therapy in combination with arthroscopic abrasion arthroplasty (AAA) in advanced knee osteoarthritis (OA). Materials & methods: 27 patients with Grade IV OA of the knee underwent AAA and ADMSC therapy (50 × 106 ADMSCs at baseline and 6 months). Clinical outcome was assessed over 36 months. Structural change was determined using MRI. Results: Treatment was well tolerated with no serious adverse events. Clinically significant improvements in pain and function were observed. Reproducible hyaline-like cartilage regeneration was seen in all participants. Conclusion: ADMSC therapy combined with AAA in Grade IV OA results in reproducible pain, functional and structural improvements. This represents a joint preservation technique for patients with advanced OA of the knee. Trial registration number: ACTRN12617000638336.

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          Author and article information

          Journal
          Regen Med
          Regenerative medicine
          Future Medicine Ltd
          1746-076X
          1746-0751
          Aug 2020
          : 15
          : 8
          Affiliations
          [1 ] School of Biomedical Sciences, Charles Sturt University, Orange, NSW, Australia.
          [2 ] Magellan Stem Cells, Box Hill, Victoria, Australia.
          [3 ] Melbourne Stem Cell Centre, Box Hill, Victoria, Australia.
          [4 ] Department of Chemistry and Biotechnology, Swinburne University of Technology, Melbourne, Victoria, Australia.
          [5 ] Orthopaedics Sports Arthroplasty, Melbourne, Victoria, Australia.
          [6 ] Orthosport Victoria, Melbourne, Victoria, Australia.
          [7 ] School of Primary Healthcare, Faculty of Medicine, Monash University, Monash, Victoria, Australia.
          Article
          10.2217/rme-2020-0128
          33084503
          3e44fd88-cead-4512-b0f5-da4d90fd3796
          History

          osteoarthritis,cartilage,knee,mesenchymal stem cells,regeneration

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