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      The Effect of Non-immersive Virtual Reality Exergames Versus Band Stretching on Cardiovascular and Cerebral Hemodynamic Response: A Functional Near-Infrared Spectroscopy Study

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          Abstract

          Background

          Exercise is one of the effective ways to improve cognition. Different forms of exercises, such as aerobic exercise, resistance exercise, and coordination exercise, have different effects on the improvement of cognitive impairment. In recent years, exergames based on Non-Immersive Virtual Reality (NIVR-Exergames) have been widely used in entertainment and have gradually been applied to clinical rehabilitation. However, the mechanism of NIVR-Exergames on improving motor cognition has not been clarified. Therefore, the aim of this study is to find whether NIVR-Exergames result in a better neural response mechanism to improve the area of the cerebral cortex related to motor cognition under functional near-infrared spectroscopy (fNIRS) dynamic monitoring in comparison with resistance exercise (resistance band stretching).

          Methods

          A cross-over study design was adopted in this study, and 15 healthy young subjects (18–24 years old) were randomly divided into group A ( n = 8) and group B ( n = 7) according to a computerized digital table method. Task 1 was an NIVR-Exergame task, and Task 2 was resistance band stretching. Group A first performed Task 1, rested for 30 min (i.e., a washout period), and then performed Task 2. Group B had the reverse order. The fNIRS test was synchronized in real time during exercise tasks, and heart rate measurements, blood pressure measurements, and 2-back task synchronization fNIRS tests were performed at baseline, Post-task 1, and Post-task 2. The primary outcomes were beta values from the general linear model (GLM) in different regions of interest (ROIs), and the secondary outcomes were heart rate, blood pressure, reaction time of 2-back, and accuracy rate of 2-back.

          Results

          The activation differences of Task 1 and Task 2 in the right premotor cortex (PMC) ( P = 0.025) and the left PMC ( P = 0.011) were statistically significant. There were statistically significant differences in the activation of the right supplementary motor area (SMA) ( P = 0.007), left dorsolateral prefrontal cortex (DLPFC) ( P = 0.031), left and right PMC ( P = 0.005; P = 0.002) between baseline and Post-task 1. The differences in systolic pressure (SBP) between the two groups at three time points among women were statistically significant ( P1 = 0.009, P2 < 0.001, P3 = 0.044).

          Conclusion

          In this study, we found that NIVR-Exergames combined with motor and challenging cognitive tasks can promote the activation of SMA, PMC and DLPFC in healthy young people compared with resistance exercise alone, providing compelling preliminary evidence of the power for the rehabilitation of motor and cognitive function in patients with central nervous system diseases.

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          G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences

          G*Power (Erdfelder, Faul, & Buchner, 1996) was designed as a general stand-alone power analysis program for statistical tests commonly used in social and behavioral research. G*Power 3 is a major extension of, and improvement over, the previous versions. It runs on widely used computer platforms (i.e., Windows XP, Windows Vista, and Mac OS X 10.4) and covers many different statistical tests of the t, F, and chi2 test families. In addition, it includes power analyses for z tests and some exact tests. G*Power 3 provides improved effect size calculators and graphic options, supports both distribution-based and design-based input modes, and offers all types of power analyses in which users might be interested. Like its predecessors, G*Power 3 is free.
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            The diagnosis and management of mild cognitive impairment: a clinical review.

            Cognitive decline is a common and feared aspect of aging. Mild cognitive impairment (MCI) is defined as the symptomatic predementia stage on the continuum of cognitive decline, characterized by objective impairment in cognition that is not severe enough to require help with usual activities of daily living.
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              Worldwide stroke incidence and early case fatality reported in 56 population-based studies: a systematic review.

              This systematic review of population-based studies of the incidence and early (21 days to 1 month) case fatality of stroke is based on studies published from 1970 to 2008. Stroke incidence (incident strokes only) and case fatality from 21 days to 1 month post-stroke were analysed by four decades of study, two country income groups (high-income countries and low to middle income countries, in accordance with the World Bank's country classification) and, when possible, by stroke pathological type: ischaemic stroke, primary intracerebral haemorrhage, and subarachnoid haemorrhage. This Review shows a divergent, statistically significant trend in stroke incidence rates over the past four decades, with a 42% decrease in stroke incidence in high-income countries and a greater than 100% increase in stroke incidence in low to middle income countries. In 2000-08, the overall stroke incidence rates in low to middle income countries have, for the first time, exceeded the level of stroke incidence seen in high-income countries, by 20%. The time to decide whether or not stroke is an issue that should be on the governmental agenda in low to middle income countries has now passed. Now is the time for action.
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                Author and article information

                Contributors
                Journal
                Front Hum Neurosci
                Front Hum Neurosci
                Front. Hum. Neurosci.
                Frontiers in Human Neuroscience
                Frontiers Media S.A.
                1662-5161
                12 July 2022
                2022
                : 16
                : 902757
                Affiliations
                [1] 1Department of Rehabilitation Medicine, The Fifth Affiliated Hospital of Guangzhou Medical University , Guangzhou, China
                [2] 2Department of Rehabilitation Medicine, The Fifth College of Guangzhou Medical University , Guangzhou, China
                [3] 3Department of Clinical Nutrition, The Fifth Affiliated Hospital of Guangzhou Medical University , Guangzhou, China
                Author notes

                Edited by: Hasan Ayaz, Drexel University, United States

                Reviewed by: Fares Al-Shargie, American University of Sharjah, United Arab Emirates; Dang Khoa Nguyen, Université de Montréal, Canada

                *Correspondence: Qiang Lin, qianglin0925@ 123456gzhmu.edu.cn

                These authors share first authorship

                This article was submitted to Cognitive Neuroscience, a section of the journal Frontiers in Human Neuroscience

                Article
                10.3389/fnhum.2022.902757
                9314640
                3e0e661b-2e85-4fcd-a002-929d562cc67f
                Copyright © 2022 Zheng, You, Du, Zhang, Peng, Liang, Zhao, Ou, Jiang, Feng, Yilifate and Lin.

                This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

                History
                : 23 March 2022
                : 13 June 2022
                Page count
                Figures: 6, Tables: 4, Equations: 0, References: 64, Pages: 13, Words: 9037
                Categories
                Neuroscience
                Original Research

                Neurosciences
                functional near-infrared spectroscopy (fnirs),nivr-exergames,resistance exercise,cognition,motor,neural response mechanism of cerebral cortex,2-back

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