A new member of the frizzled family from Drosophila functions as a Wingless receptor.

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Receptors for Wingless and other signalling molecules of the Wnt gene family have yet to be identified. We show here that cultured Drosophila cells transfected with a novel member of the frizzled gene family in Drosophila, Dfz2, respond to added Wingless protein by elevating the level of the Armadillo protein. Moreover, Wingless binds to Drosophila or human cells expressing Dfz2. These data demonstrate that Dfz2 functions as a Wingless receptor, and they imply, in general, that Frizzled proteins are receptors for the Wnt signalling molecules.

Related collections

Author and article information

Journal

Journal ID (iso-abbrev): Nature

Title: Nature

Publisher: Springer Science and Business Media LLC

ISSN: 0028-0836

ISSN (Print): 0028-0836

Publication date (Electronic): Jul 18 1996

Volume: 382

Issue: 6588

Affiliations

[1 ] Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

Article

DOI: 10.1038/382225a0

PubMed ID: 8717036

SO-VID: 3df14f0d-511e-4ad8-ae94-f4ac5b1b45d0

History

Data availability:

Comments

Comment on this article

scite_

Smart Citations

Citing PublicationsSupportingMentioningContrasting

View Citations

See how this article has been cited at scite.ai

scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.