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Abstract
Glycogen synthase kinase-3 (GSK3) is now recognized as a key component of a surprisingly
large number of cellular processes and diseases. Several mechanisms play a part in
controlling the actions of GSK3, including phosphorylation, protein complex formation,
and subcellular distribution. These are used to control and direct the far-reaching
influences of GSK3 on cellular structure, growth, motility and apoptosis. Dysregulation
of GSK3 is linked to several prevalent pathological conditions, such as diabetes and/or
insulin resistance, and Alzheimer's disease. Therefore, much effort is currently directed
towards understanding the functions and control of GSK3, and identifying methods capable
of diminishing the deleterious impact of GSK3 in pathological conditions.