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      Refractory humeral non-union: treatment with photodynamic intramedullary implant IlluminOss® and internal fixation

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          Abstract

          Surgically treated humeral shaft fractures can develop into pseudoarthrosis (PSA). Even if PSA is treated according to the proposed literature, refractory non-union of the humerus can be determined. Due to the rarity of this condition, we report our experience in the management of refractory pseudarthrosis of the humerus at the IRCCS Galeazzi Orthopedic Institute (Milan, Italy). We used internal fixation with plate and screws associated with the implant of the IlluminOss® Photodynamic Bone Stabilization System to increase bone stability and improve anchoring of the implant medium. This combined treatment allowed the consolidation of the complex fracture despite the bone loss, ensuring excellent stability of the fracture stumps and constituting a flexible and stable system with the most favourable biomechanical conditions. An increase in refractory PSA cases is likely in the future, due to a higher incidence of surgically treated humeral shaft fractures than in the past. Further studies on the effectiveness of the combined use of plate and screw and the IlluminOss® system will be indispensable. (www.actabiomedica.it)

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          Non-union bone fractures

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            Humeral shaft fractures: national trends in management

            Background The incidence of humeral shaft fractures has been increasing over time. This represents a growing public health concern in a climate of cost containment. The purpose of this study is to analyze national trends in surgical management of humeral shaft fractures and determine factors predictive of surgical intervention. Materials and methods Humeral shaft fractures were identified by the International Classification of Diseases, Ninth Revision, Clinical Modification codes 812.21 and 812.31 in the United States Nationwide Inpatient Sample from 2002 to 2011. Open reduction and internal fixation (ORIF) was identified by code 79.31 (ORIF, humerus). Other case codes analyzed were 79.01 (closed reduction without internal fixation), 79.11 (closed reduction with internal fixation), and 79.21 (open reduction without internal fixation). Multivariate regression analysis was utilized to determine predictive factors for utilization of ORIF. Results 27,908 humeral shaft fractures were identified. Utilization of ORIF increased from 47.2% of humeral shaft fractures in 2002 to 60.3% in 2011. Demographically, patients who underwent ORIF were younger (51.5 versus 59.7 years, p < 0.001; odds ratio 0.87 per decade of age). There were modest increases in ORIF usage with private insurance, open fracture, and hospital size, which persisted with multivariate regression analysis. Surprisingly, there was a tendency to shift from a slight increase in ORIF for males with the bivariate case to a slight preference for females in the multivariate case. Conclusion Utilization of ORIF for humeral shaft fractures has been steadily increasing with time. Surgical intervention was more common with younger patients, female gender, private insurance, and larger hospital size. The increasing incidence of surgical management for humeral shaft fractures may represent a public health burden given the historical success of non-operative management. Level of evidence IV.
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              Union rate after operative treatment of humeral shaft nonunion – A systematic review

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                Author and article information

                Journal
                Acta Biomed
                Acta Biomed
                Acta Bio Medica : Atenei Parmensis
                Mattioli 1885 (Italy )
                0392-4203
                2531-6745
                2022
                07 December 2022
                : 93
                : Suppl 1
                : e2022340
                Affiliations
                [1 ] Trauma Surgery Department, IRCCS Orthopedic Institute Galeazzi, Milan, Italy
                [2 ] Department of Anatomical, Histological, Forensic and Orthopedic Sciences, “Sapienza” University of Rome, 00161 Rome, Italy
                Author notes
                Correspondence: Stefania Fozzato MD, PhD Trauma Surgery Department, IRCCS Orthopedic Institute Galeazzi, Via Cristina Belgioiso 173, 20157 Milano, Italy E-mail: ste.fozzato@ 123456gmail.com ORCID: https://orcid.org/0000-0002-6368-2614
                Article
                ACTA-93-340
                10.23750/abm.v93iS1.13773
                10510959
                36477018
                3d56d2a2-ac57-4ced-9889-eff9bb46998f
                Copyright: © 2022 ACTA BIO MEDICA SOCIETY OF MEDICINE AND NATURAL SCIENCES OF PARMA

                This work is licensed under a Creative Commons Attribution 4.0 International License

                History
                : 08 October 2022
                : 09 November 2022
                Categories
                Case Report

                non-union,intramedullary implant,refractory humeral non-union,pseudoarthrosis,illuminoss®,humeral shaft fractures

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