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<h5 class="section-title" id="d3317729e129">Objective</h5>
<p id="P1">Cross-sectional, longitudinal, and genetic associations exist between irritability
and depression. Prior studies have examined developmental trajectories of irritability,
clinical outcomes, and associations with child and familial depression. However, studies
have not integrated neurobiological measures. The current study examined developmental
trajectories of irritability, clinical outcomes, and cortical structure among preschoolers
oversampled for depressive symptoms.
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<h5 class="section-title" id="d3317729e134">Method</h5>
<p id="P2">Beginning at 3–5 years old, a sample of 271 children enriched for early
depressive
symptoms were assessed longitudinally by clinical interview. Latent class mixture
models identified trajectories of irritability severity. Risk factors, clinical outcomes,
and cortical thickness were compared across trajectory classes. Cortical thickness
measures were extracted from three waves of magnetic resonance imaging at 7–12 years
of age.
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<h5 class="section-title" id="d3317729e139">Results</h5>
<p id="P3">Three trajectory classes were identified among these youth: 53.50% of children
exhibited
elevated irritability during preschool that declined longitudinally, 30.26% exhibited
consistently low irritability, and 16.24% exhibited consistently elevated irritability.
Compared to other classes, the elevated irritability class exhibited higher rates
of maternal depression, early life adversity, later psychiatric diagnoses and functional
impairment. Further, elevated baseline irritability predicted later depression beyond
adversity and personal and maternal depression history. The elevated irritability
class exhibited thicker cortex in the left superior frontal and temporal gyri and
the right inferior parietal lobule.
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<h5 class="section-title" id="d3317729e144">Conclusion</h5>
<p id="P4">Irritability manifested with specific developmental trajectories in this
sample enriched
for early depression. Persistently elevated irritability predicted poor psychiatric
outcomes, higher risk for later depression, and reduced overall function later in
development. Greater frontal, temporal, and parietal cortical thickness was also found,
providing neural correlates of this risk trajectory.
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