Current and Novel Biomarkers of Progression Risk in Children with Chronic Kidney Disease

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Abstract

Background: Due to the complexity of chronic kidney disease (CKD) pathophysiology, biomarkers representing different mechanistic pathways have been targeted for the study and development of novel biomarkers. The discovery of clinically useful CKD biomarkers would allow for the identification of those children at the highest risk of kidney function decline for timely interventions and enrollment in clinical trials. Summary: Glomerular filtration rate and proteinuria are traditional biomarkers to classify and prognosticate CKD progression in clinical practice but have several limitations. Over the recent decades, novel biomarkers have been identified from blood or urine with metabolomic screening studies, proteomic screening studies, and an improved knowledge of CKD pathophysiology. This review highlights promising biomarkers associated with the progression of CKD that could potentially serve as future prognostic markers in children with CKD. Key Messages: Further studies are needed in children with CKD to validate putative biomarkers, particularly candidate proteins and metabolites, for improving clinical management.

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Author and article information

Journal

Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Abbreviated Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 2024

Publication date (Print): January 2024

Publication date (Electronic): 15 May 2023

Volume: 148

Issue: 1

Pages: 1-10

Affiliations

[_a] _aDepartment of Pediatrics, Taibah University College of Medicine, Medina, Saudi Arabia

[_b] _bDepartment of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA

[_c] _cDivision of Nephrology, Children’s Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA

[_d] _dDepartment of Epidemiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA

[_e] _eDepartment of Pediatrics, Section of Nephrology, Clinical and Translational Research Accelerator, Yale School of Medicine, New Haven, Connecticut, USA

Author notes

*Jason H. Greenberg, jason.greenberg@yale.edu

Author information

Ibrahim Sandokji https://orcid.org/0000-0003-1395-9555

Yunwen Xu https://orcid.org/0000-0002-5946-2272

Jason H. Greenberg https://orcid.org/0000-0001-5874-1109

Article

Publisher ID: 530918 Other ID: Nephron 2024;148:1–10

DOI: 10.1159/000530918

PubMed ID: 37232009

SO-VID: 3cb11550-643b-4062-86f4-dd6f87f0be2f

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.

History

Date received : 15 September 2022

Date accepted : 18 February 2023

Page count

Figures: 3, Pages: 10

Funding

This research was supported by NIH career development grant K08DK110536 (to J. Greenberg). This research was also supported by the CKD Biomarkers Consortium (NIDDK grant U01 DK106982) to S. Furth and M. Denburg. M. Denburg was also supported by R21 AT009752. S. Furth is supported by the NIH K24DK078737 and U01-DK-66174. The CKiD study is funded by the NIDDK, with additional funding from the National Institute of Child Health and Human Development, and the National Heart, Lung, and Blood Institute (U01-DK-66143, U01-DK-66174, U01-DK-082194, U01-DK-66116). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIDDK, the National Institutes of Health, the Department of Health and Human Services, or the government of the USA.

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