Effects of Long-Term Selection in the Border Collie Dog Breed: Inbreeding Purge of Canine Hip and Elbow Dysplasia

Abstract

Simple Summary

For dog breeders, health is one of the main criteria when choosing a breeding animal; thus, selection for good anatomy is the key to reduce orthopedic disorders. In many dog breeds, radiographic screening for canine hip and elbow dysplasia is a compulsory test for breeding; however, these multifactorial traits are determined by genetic and environmental factors. Therefore, it is extremely difficult to eliminate these disorders from the population. In natural selection, such traits can be “purged” out of the population with inbreeding. The study aimed to examine the inbreeding-purge of canine hip and elbow dysplasia in the border collie breed. The main conclusion was that over-representation of homozygous individuals may have a positive effect on hip and elbow conformation.

Abstract

Pedigree data of 13,339 border collie dog was collected along with canine hip dysplasia (CHD) and canine elbow dysplasia (CED) records (1352 CHD and 524 CED), and an inbreeding–purging (IP) model was created. Ancestral inbreeding coefficients were calculated by using a gene dropping simulation method with GRain 2.2 software. Cumulative logit models (CLM) for CHD and CED were fitted using a logit-link Poisson distribution and the classical (F_ _W), and ancestral inbreeding (F_ _BAL, F_ _KAL, and F_ _{KAL_NEW}) coefficients as linear regression coefficients. The effective population size was calculated from F_ _W and decreased in the examined period along with an increase of F_ _W; however, slight differences were found as a consequence of breeding dog imports. CHD values were lowered by the expansion of F_ _BAL, as the alleles had been inbred in the past. For CHD, signs of purging were obtained. There was a positive trend regarding the breeding activity (both sire and dam of the future litters should be screened and certified free from CHD and CED), as years of selection increased the frequency of alleles with favorable hip and elbow conformation. Division of the ancestral inbreeding coefficient showed that alleles that had been identical by descent (IBD) for the first time (F_ _{KAL_NEW}) had a negative effect on both traits, while F_ _KAL has shown favorable results for alleles IBD in past generations. Some authors had proven this phenomenon in captive populations or experimental conditions; however, no evidence of inbreeding purge has ever been described in dog populations. Despite the various breeding practices, it seems that alleles of these polygenic disorders could be successfully purged out of the population with long-term selection.