Therapeutic potential of Coptis chinensis for arthritis with underlying mechanisms – ScienceOpen
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      Therapeutic potential of Coptis chinensis for arthritis with underlying mechanisms

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          Abstract

          Arthritis is a common degenerative disease of joints, which has become a public health problem affecting human health, but its pathogenesis is complex and cannot be eradicated. Coptis chinensis (CC) has a variety of active ingredients, is a natural antibacterial and anti-inflammatory drug. In which, berberine is its main effective ingredient, and has good therapeutic effects on rheumatoid arthritis (RA), osteoarthritis (OA), gouty arthritis (GA). RA, OA and GA are the three most common types of arthritis, but the relevant pathogenesis is not clear. Therefore, molecular mechanism and prevention and treatment of arthritis are the key issues to be paid attention to in clinical practice. In general, berberine, palmatine, coptisine, jatrorrhizine, magnoflorine and jatrorrhizine hydrochloride in CC play the role in treating arthritis by regulating Wnt1/β-catenin and PI3K/AKT/mTOR signaling pathways. In this review, active ingredients, targets and mechanism of CC in the treatment of arthritis were expounded, and we have further explained the potential role of AHR, CAV1, CRP, CXCL2, IRF1, SPP1, and IL-17 signaling pathway in the treatment of arthritis, and to provide a new idea for the clinical treatment of arthritis by CC.

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          The pathogenesis of rheumatoid arthritis.

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            The PI3K/AKT/mTOR signaling pathway in osteoarthritis: a narrative review

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              The aryl hydrocarbon receptor: multitasking in the immune system.

              The aryl hydrocarbon receptor (AhR), for many years almost exclusively studied by the pharmacology/toxicology field for its role in mediating the toxicity of xenobiotics such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), has more recently attracted the attention of immunologists. The evolutionary conservation of this transcription factor and its widespread expression in the immune system point to important physiological functions that are slowly being unraveled. In particular, the emphasis is now shifting from the role of AhR in the xenobiotic pathway toward its mode of action in response to physiological ligands. In this article, we review the current understanding of the molecular interactions and functions of AhR in the immune system in steady state and in the presence of infection and inflammation, with a focus on barrier organs such as the skin, the gut, and the lung.
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                Author and article information

                Contributors
                Journal
                Front Pharmacol
                Front Pharmacol
                Front. Pharmacol.
                Frontiers in Pharmacology
                Frontiers Media S.A.
                1663-9812
                11 August 2023
                2023
                : 14
                : 1243820
                Affiliations
                [1] 1 Haihe Laboratory of Modern Chinese Medicine , Tianjin, China
                [2] 2 National Key Laboratory of Chinese Medicine Modernization , Tianjin University of Traditional Chinese Medicine , Tianjin, China
                [3] 3 School of Chinese Materia Medica , Tianjin University of Traditional Chinese Medicine , Tianjin, China
                [4] 4 Department of Geriatric , Fourth Teaching Hospital of Tianjin University of Traditional Chinese Medicine , Tianjin, China
                Author notes

                Edited by: Sirajudheen Anwar, University of Hail, Saudi Arabia

                Reviewed by: Sakeel Ahmed, NIPER-A, India

                Mohd Rabi Bazaz, National Institute of Pharmaceutical Education and Research, India

                Ziaur Rahman, Thomas Jefferson University, United States

                *Correspondence: Miaomiao Jiang, miaomiaojiang@ 123456tjutcm.edu.cn ; Jing Zhao, zhaojing_tju@ 123456tjutcm.edu.cn
                [ † ]

                These authors have contributed equally to this work

                Article
                1243820
                10.3389/fphar.2023.1243820
                10450980
                37637408
                3c2296e6-e7e4-4c25-b90b-f4a7283a127f
                Copyright © 2023 Li, Tian, Guo, Li, Ma, Jiang and Zhao.

                This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

                History
                : 21 June 2023
                : 01 August 2023
                Funding
                This work was supported by the National Natural Science Foundation of China (grant No. 81973699, No. 82274361).
                Categories
                Pharmacology
                Review
                Custom metadata
                Inflammation Pharmacology

                Pharmacology & Pharmaceutical medicine
                coptis chinensis,arthritis,berberine,wnt1/β-catenin signaling pathway,pi3k/akt/mtor signaling pathway

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