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      Quantitative comparison of 21 protocols for labeling hippocampal subfields and parahippocampal subregions in in vivo MRI: towards a harmonized segmentation protocol.

      1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 11 , 5 , 9 , 17 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 12 , 29 , 27 , 30 , 31 , 32 , 33 , 30 , 34 , 35 , 36 , 2 , 16 , 31 , 24
      NeuroImage
      CA1, CA2, CA3, Dentate gyrus, Entorhinal cortex, Hippocampal subfields, Hippocampus, Magnetic resonance imaging, Medial temporal lobe, Parahippocampal gyrus, Perirhinal cortex, Segmentation, Subiculum, Unified protocol

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          Abstract

          An increasing number of human in vivo magnetic resonance imaging (MRI) studies have focused on examining the structure and function of the subfields of the hippocampal formation (the dentate gyrus, CA fields 1-3, and the subiculum) and subregions of the parahippocampal gyrus (entorhinal, perirhinal, and parahippocampal cortices). The ability to interpret the results of such studies and to relate them to each other would be improved if a common standard existed for labeling hippocampal subfields and parahippocampal subregions. Currently, research groups label different subsets of structures and use different rules, landmarks, and cues to define their anatomical extents. This paper characterizes, both qualitatively and quantitatively, the variability in the existing manual segmentation protocols for labeling hippocampal and parahippocampal substructures in MRI, with the goal of guiding subsequent work on developing a harmonized substructure segmentation protocol.

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          Author and article information

          Journal
          Neuroimage
          NeuroImage
          1095-9572
          1053-8119
          May 1 2015
          : 111
          Affiliations
          [1 ] Penn Image Computing and Science Laboratory, Department of Radiology, University of Pennsylvania, USA. Electronic address: pauly2@upenn.edu.
          [2 ] Cerebral Imaging Centre, Douglas Mental Health University Institute, McGill University, Canada.
          [3 ] A.A. Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, USA.
          [4 ] Institute of Gerontology, Wayne State University, USA.
          [5 ] Department of Neurology and Neurological Sciences, Stanford University School of Medicine, USA; Stanford Center for Memory Disorders, USA.
          [6 ] LENITEM (Laboratory of Epidemiology, Neuroimaging and Telemedicine), IRCCS Centro S. Giovanni di Dio Fatebenefratelli, Italy.
          [7 ] LENITEM (Laboratory of Epidemiology, Neuroimaging and Telemedicine), IRCCS Centro S. Giovanni di Dio Fatebenefratelli, Italy; Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
          [8 ] Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, USA.
          [9 ] Department of Psychology, Stanford University, USA.
          [10 ] Cerebral Imaging Centre, Douglas Mental Health University Institute, McGill University, Canada; Department of Psychiatry, Department of Biomedical Engineering, McGill University, Canada.
          [11 ] INSERM U1077, Universitè de Caen Basse-Normandie, UMR-S1077, Ecole Pratique des Hautes Etudes, CHU de Caen, U1077, Caen, France.
          [12 ] Institute of Gerontology, Wayne State University, USA; Psychology Department, Wayne State University, USA.
          [13 ] Department of Psychology, New York University, USA; Center for Neural Science, New York University, USA.
          [14 ] Allen Institute for Brain Science, USA.
          [15 ] Center for Neuroscience, University of California, Davis, USA; Department of Psychology, University of California, Davis, USA.
          [16 ] Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Netherlands.
          [17 ] Center for Neuroscience, University of California, Davis, USA.
          [18 ] Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada.
          [19 ] A.A. Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, USA; Basque Center on Cognition, Brain and Language (BCBL), Donostia-San Sebastian, Spain.
          [20 ] Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada; Centre for Neuroscience, University of Alberta, Edmonton, Alberta, Canada.
          [21 ] Department of Radiology, University of California, San Francisco, USA; Center for Imaging of Neurodegenerative Diseases, San Francisco VA Medical Center, USA.
          [22 ] Rotman Research Institute, Baycrest, Canada.
          [23 ] VA Boston Healthcare System, USA.
          [24 ] Department of Radiology, Stanford University, USA.
          [25 ] Penn Image Computing and Science Laboratory, Department of Radiology, University of Pennsylvania, USA; Department of Biostatistics, University of Pennsylvania, USA.
          [26 ] Department of Psychology, The University of Texas at Austin, USA; Center for Learning and Memory, The University of Texas at Austin, USA; Department of Neuroscience, The University of Texas at Austin, USA.
          [27 ] McGill Centre for Studies in Aging, Faculty of Medicine, McGill University, Canada; Department of Psychology, McGill University, Canada.
          [28 ] Department of Psychology, University of California, Davis, USA; Center for Neuroscience, University of California, Davis, USA.
          [29 ] Department of Psychology, The University of Texas at Austin, USA; Center for Learning and Memory, The University of Texas at Austin, USA.
          [30 ] Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, USA.
          [31 ] Department of Neurobiology and Behavior, University of California, Irvine, USA.
          [32 ] Department of Neurosurgery, University of California, Los Angeles, USA.
          [33 ] Department of Psychology, New York University, USA.
          [34 ] A.A. Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, USA; Department of Applied Mathematics and Computer Science, Technical University of Denmark, Denmark.
          [35 ] Department of Psychology, Stanford University, USA; Neurosciences Program, Stanford University, USA.
          [36 ] Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, USA; Department of Radiology, Northwestern University Feinberg School of Medicine, USA.
          Article
          S1053-8119(15)00007-5 NIHMS660815
          10.1016/j.neuroimage.2015.01.004
          25596463
          3baf4d5e-44ca-4c69-b650-f1763698a560
          Copyright © 2015 Elsevier Inc. All rights reserved.
          History

          CA1,CA2,CA3,Dentate gyrus,Entorhinal cortex,Hippocampal subfields,Hippocampus,Magnetic resonance imaging,Medial temporal lobe,Parahippocampal gyrus,Perirhinal cortex,Segmentation,Subiculum,Unified protocol

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