Erratum to: Synergistic anti-malarial action of cryptolepine and artemisinins

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Abstract

Erratum to: Malar J (2016) 15:89 DOI 10.1186/s12936-016-1137-5 After publication of the original article [1], the authors found that there was an error in the first sentence of the ‘Conclusions’ section: “The combination of CPE with the artemisinins showed a synergistic effect both in vivo and in vitro against P. falciparum 3D7 and P. berghei NK-65, respectively.” Within this sentence, the appearance of ‘P. falciparum 3D7’ and ‘P. berghei NK-65’ should have been reversed. The sentence in the original article has been corrected to read as follows: “The combination of CPE with the artemisinins showed a synergistic effect both in vivo and in vitro against P. berghei NK-65 and P. falciparum 3D7, respectively.”

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Synergistic anti-malarial action of cryptolepine and artemisinins

Arnold D. Forkuo, Charles Ansah, Kwesi Boadu … (2016)

Background Cryptolepine (CPE) is the major indoloquinoline isolated from the popular West African anti-malarial plant, Cryptolepis sanguinolenta. CPE possesses various pharmacological activities with potent anti-malarial activity against both chloroquine (CQ)-resistant and -sensitive strains. The search for safe and novel anti-malarial agents and combinations to delay resistance development to Plasmodium falciparum directed this work aimed at evaluating the anti-malarial interaction and safety of CPE in combination with some artemisinin derivatives. Methods The in vitro SYBR Green I, fluorescent-based, drug sensitivity assay using a fixed ratio method was carried out on the CQ-sensitive plasmodial strain 3D7 to develop isobolograms from three CPE-based combinations with some artemisinin derivatives. CPE and artesunate (ART) combinations were also evaluated using the Rane’s test in ICR mice infected with Plasmodium berghei NK-65 strains in a fixed ratio combination (1:1) and fractions of their ED50s in order to determine the experimental ED50 (Zexp) of the co-administered compounds. Isobolograms were constructed to compare the Zexp to the Zadd. Results CPE exhibited promising synergistic interactions in vitro with ART, artemether and dihydroartemisinin. In vivo, CPE combination with ART again showed synergy as the Zexp was 1.02 ± 0.02, which was significantly less than the Zadd of 8.3 ± 0.31. The haematological, biochemical, organ/body weight ratio and histopathology indices in the rats treated with CPE at all doses (25, 50, 100 mg kg−1 po) and in combination with ART (4 mg kg−1) showed no significant difference compared to the control group. Conclusion The combination of CPE with the artemisinin derivatives were safe in the rodent model and showed a synergistic anti-malarial activity in vivo and in vitro. This study supports the basis for the selection of CPE as a prospective lead compound as the search for new anti-malarial combinations continues.

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Author and article information

Contributors

Charles Ansah: cansah.pharm@knust.edu.gh

Journal

Journal ID (nlm-ta): Malar J

Journal ID (iso-abbrev): Malar. J

Title: Malaria Journal

Publisher: BioMed Central (London )

ISSN (Electronic): 1475-2875

Publication date (Electronic): 16 March 2016

Publication date PMC-release: 16 March 2016

Publication date Collection: 2016

Volume: 15

Electronic Location Identifier: 171

Affiliations

[ ]Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana

[ ]Department of Biomedical and Forensic Sciences, School of Biological Science, College of Agriculture and Natural Sciences, University of Cape Coast, Cape Coast, Ghana

[ ]Department of Immunology, Noguchi Memorial Institute for Biomedical Research, University of Ghana, Legon, Ghana

Article

Publisher ID: 1223

DOI: 10.1186/s12936-016-1223-8

PMC ID: 4794919

PubMed ID: 26984022

SO-VID: 3bac610a-a13d-4a3c-9318-6dac27773dd4

License:

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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ScienceOpen disciplines: Infectious disease & Microbiology

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ScienceOpen disciplines: Infectious disease & Microbiology

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Erratum to: Synergistic anti-malarial action of cryptolepine and artemisinins

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