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      Outcomes of Composite Grafts for Pediatric Fingertip Amputations: A Systematic Review

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          Abstract

          Introduction  The aim of this study was to explore the outcomes of composite grafts in fingertip amputations in children as well as the contributing factors that may affect outcomes.

          Methods  Literature search was conducted across six databases in March 2022 to select studies on the use of composite grafts on fingertip amputations in the pediatric population.

          Results  Twelve articles with 735 composite grafts were identified for review. Most fingertip injuries occurred in the less than 5-year age group and were due to crush type injuries. In studies that reported “complete” graft take as a separate outcome measure, 17.3% of fingertips with this result were observed. In the studies that reported “complete” and “partial” graft take together as an outcome measure, 81.6% of fingertips achieved this outcome. A lower proportion of failed graft take was observed in more distal fingertip amputations. Infection (3.8%) and nail abnormalities (3.4%) were the most common complications following composite grafting.

          Conclusion  Composite grafting can be considered as a useful method of treatment in this population. Clinicians should be aware of the potential complications following this method of treatment such as infection and nail abnormalities. More proximal fingertip amputations may warrant other surgical interventions (beyond Level II on the modified Ishikawa/Ishikawa classification). Significant heterogeneity was observed within the studies, mainly due to lack of standardization in assessment and reporting of outcomes.

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          Most cited references27

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          ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions

          Non-randomised studies of the effects of interventions are critical to many areas of healthcare evaluation, but their results may be biased. It is therefore important to understand and appraise their strengths and weaknesses. We developed ROBINS-I (“Risk Of Bias In Non-randomised Studies - of Interventions”), a new tool for evaluating risk of bias in estimates of the comparative effectiveness (harm or benefit) of interventions from studies that did not use randomisation to allocate units (individuals or clusters of individuals) to comparison groups. The tool will be particularly useful to those undertaking systematic reviews that include non-randomised studies.
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            Twenty years' experience of limb replantation--review of 293 upper extremity replants.

            S Tamai (1982)
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              Factors affecting composite graft survival in digital tip amputations.

              Distal fingertip amputations present the hand surgeon with a myriad of treatment options. Composite tissue replantation offers the patient the possibility of maintaining digital length and function. The purpose of this study was to determine the efficacy of this treatment modality and to support its use. During a 2.5-year period, 53 patients with 57 digital tip amputations distal to the distal interphalangeal (DIP) joint underwent composite tissue grafting of the tip with minimal defatting. All patients were evaluated in a prospective manner. Specific information regarding the patient and the injury were recorded. The survival rates for amputations distal to the eponychium and between the DIP joint and eponychium were 58% and 43%, respectively. Smoking was the only significant factor that had a strong, independent association with graft loss. Age older than 18 years and alcohol use appeared only initially to have an effect on graft survival because they were so closely linked with smoking. Diabetes mellitus and crush-type injuries may potentially predispose a graft to fail, but a larger sample size is needed to prove this with significance. There were no infections or serious complications, even in those grafts that failed. After reviewing the data, the authors recommend using composite tissue replantation for fingertip amputations distal to the DIP joint in nonsmokers.
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                Author and article information

                Journal
                Indian J Plast Surg
                Indian J Plast Surg
                10.1055/s-00042863
                Indian Journal of Plastic Surgery : Official Publication of the Association of Plastic Surgeons of India
                Thieme Medical and Scientific Publishers Pvt. Ltd. (A-12, 2nd Floor, Sector 2, Noida-201301 UP, India )
                0970-0358
                1998-376X
                28 July 2023
                August 2023
                1 July 2023
                : 56
                : 4
                : 310-319
                Affiliations
                [1 ]Birmingham Women's and Children's Hospital, Birmingham, United Kingdom
                [2 ]Sheffield Medical School, Sheffield University, Sheffield, United Kingdom
                [3 ]Birmingham Medical School, Birmingham University, Birmingham, United Kingdom
                [4 ]Keele Medical School, Keele University, Newcastle-under-Lyme United Kingdom
                Author notes
                Address for correspondence Yangmyung Ma, MBBS Birmingham Women's and Children's Hospital Birmingham, B4 6NHUnited Kingdom yangmyung.ma2@ 123456nhs.net
                Author information
                http://orcid.org/0000-0002-5241-9079
                http://orcid.org/0000-0002-2315-0744
                http://orcid.org/0000-0003-1118-2164
                Article
                IJPS-23-2-2087
                10.1055/s-0043-1771295
                10497336
                37705815
                3ae0bb35-100f-4c35-a67c-e9280370a981
                Association of Plastic Surgeons of India. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ )

                This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.

                History
                Categories
                Systematic Review

                Surgery
                amputations,composite graft,fingertip,pediatric
                Surgery
                amputations, composite graft, fingertip, pediatric

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