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      Interleaved practice benefits implicit sequence learning and transfer

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      Memory & Cognition
      Springer US
      Contextual interference, Serial reaction time task, Implicit learning

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          Abstract

          Compared to blocked practice, interleaved practice of different tasks leads to superior long-term retention despite poorer initial acquisition performance. This phenomenon, the contextual interference effect, is well documented in various domains but it is not yet clear if it persists in the absence of explicit knowledge in terms of fine motor sequence learning. Additionally, while there is some evidence that interleaved practice leads to improved transfer of learning to similar actions, transfer of implicit motor sequence learning has not been explored. The present studies used a serial reaction time task where participants practiced three different eight-item sequences that were either interleaved or blocked on Day 1 (training) and Day 2 (testing). In Experiment 1, the retention of the three training sequences was tested on Day 2 and in Experiment 2, three novel sequences were performed on Day 2 to measure transfer. We assessed whether subjects were aware of the sequences to determine whether the benefit of interleaved practice extends to implicitly learned sequences. Even for participants who reported no awareness of the sequences, interleaving led to a benefit for both retention and transfer compared to participants who practiced blocked sequences. Those who trained with blocked sequences were left unprepared for interleaved sequences at test, while those who trained with interleaved sequences were unaffected by testing condition, revealing that learning resulting from blocked practice may be less flexible and more vulnerable to testing conditions. These results indicate that the benefit of interleaved practice extends to implicit motor sequence learning and transfer.

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          Attentional requirements of learning: Evidence from performance measures

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            Levels of processing versus transfer appropriate processing

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              Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval.

              'New' memories are initially labile and sensitive to disruption before being consolidated into stable long-term memories. Much evidence indicates that this consolidation involves the synthesis of new proteins in neurons. The lateral and basal nuclei of the amygdala (LBA) are believed to be a site of memory storage in fear learning. Infusion of the protein synthesis inhibitor anisomycin into the LBA shortly after training prevents consolidation of fear memories. Here we show that consolidated fear memories, when reactivated during retrieval, return to a labile state in which infusion of anisomycin shortly after memory reactivation produces amnesia on later tests, regardless of whether reactivation was performed 1 or 14 days after conditioning. The same treatment with anisomycin, in the absence of memory reactivation, left memory intact. Consistent with a time-limited role for protein synthesis production in consolidation, delay of the infusion until six hours after memory reactivation produced no amnesia. Our data show that consolidated fear memories, when reactivated, return to a labile state that requires de novo protein synthesis for reconsolidation. These findings are not predicted by traditional theories of memory consolidation.
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                Author and article information

                Contributors
                juliaschorn@g.ucla.edu
                Journal
                Mem Cognit
                Mem Cognit
                Memory & Cognition
                Springer US (New York )
                0090-502X
                1532-5946
                1 April 2021
                1 April 2021
                2021
                : 49
                : 7
                : 1436-1452
                Affiliations
                GRID grid.19006.3e, ISNI 0000 0000 9632 6718, Department of Psychology, , University of California, Los Angeles, ; Los Angeles, CA 90095 USA
                Article
                1168
                10.3758/s13421-021-01168-z
                8476370
                33796961
                3ab16968-b61c-4cd9-9dbe-8548f9712896
                © The Author(s) 2021

                Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

                History
                : 9 March 2021
                Funding
                Funded by: FundRef http://dx.doi.org/10.13039/100000001, National Science Foundation;
                Award ID: BCS- 1634157
                Categories
                Article
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                © The Psychonomic Society, Inc. 2021

                Neurosciences
                contextual interference,serial reaction time task,implicit learning
                Neurosciences
                contextual interference, serial reaction time task, implicit learning

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