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      Atlantoaxial Rotatory Subluxation in a 10-Year-Old Boy

      case-report

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          Abstract

          Atlantoaxial rotatory subluxation (AARS) is the loss of normal alignment and stability of the first (atlas) and second (axis) cervical vertebrae with respect to each other. We describe the clinical challenges of managing a 10-year-old boy who presented with repetitive episodes of torticollis. Open-mouth odontoid radiograph and computed tomographic (CT) scan gave a diagnosis in ARRS, based on its characteristic imaging findings. The child was admitted multiple times for continuous halter traction in the first 6 months after symptom onset. He also experienced a temporary complication from an overcorrection with correcting neck bracing. Seven months after symptom onset, this case was discussed by a multidisciplinary spine team and referred to chiropractic clinic. Despite persistent radiographic evidence of atlantoaxial instability, after 5 months of chiropractic treatment, the child was asymptomatic with nearly full range of neck movement. He also weaned off acetaminophen he had been taking over the past year. Incidentally, bilateral gynecomastia was discovered at the surveillance after treatment. The incidental finding of innocent gynecomastia, even if common in preteen boys, brings up the topic of acetaminophen’s effects on the regulation of sex hormones that was previously overlooked.

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          Acetaminophen (Paracetamol) Use Modifies the Sulfation of Sex Hormones

          Background Acetaminophen (paracetamol) is one of the most common medications used for management of pain in the world. There is lack of consensus about the mechanism of action, and concern about the possibility of adverse effects on reproductive health. Methods We first established the metabolome profile that characterizes use of acetaminophen, and we subsequently trained and tested a model that identified metabolomic differences across samples from 455 individuals with and without acetaminophen use. We validated the findings in a European ancestry adult twin cohort of 1880 individuals (TwinsUK), and in a study of 1235 individuals of African American and Hispanic ancestry. We used genomics to elucidate the mechanisms targeted by acetaminophen. Findings We identified a distinctive pattern of depletion of sulfated sex hormones with use of acetaminophen across all populations. We used a Mendelian randomization approach to characterize the role of Sulfotransferase Family 2A Member 1 (SULT2A1) as the site of the interaction. Although CYP3A7-CYP3A51P variants also modified levels of some sulfated sex hormones, only acetaminophen use phenocopied the effect of genetic variants of SULT2A1. Overall, acetaminophen use, age, gender and SULT2A1 and CYP3A7-CYP3A51P genetic variants are key determinants of variation in levels of sulfated sex hormones in blood. The effect of taking acetaminophen on sulfated sex hormones was roughly equivalent to the effect of 35 years of aging. Interpretation These findings raise concerns of the impact of acetaminophen use on hormonal homeostasis. In addition, it modifies views on the mechanism of action of acetaminophen in pain management as sulfated sex hormones can function as neurosteroids and modify nociceptive thresholds.
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            Prenatal exposure to paracetamol/acetaminophen and precursor aniline impairs masculinisation of male brain and behaviour

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              The Dens: Normal Development, Developmental Variants and Anomalies, and Traumatic Injuries

              Accurate interpretation of cervical spine imagining can be challenging, especially in children and the elderly. The biomechanics of the developing pediatric spine and age-related degenerative changes predispose these patient populations to injuries centered at the craniocervical junction. In addition, congenital anomalies are common in this region, especially those associated with the axis/dens, due to its complexity in terms of development compared to other vertebral levels. The most common congenital variations of the dens include the os odontoideum and a persistent ossiculum terminale. At times, it is necessary to distinguish normal development, developmental variants, and developmental anomalies from traumatic injuries in the setting of acute traumatic injury. Key imaging features are useful to differentiate between traumatic fractures and normal or variant anatomy acutely; however, the radiologist must first have a basic understanding of the spectrum of normal developmental anatomy and its anatomic variations in order to make an accurate assessment. This review article attempts to provide the basic framework required for accurate interpretation of cervical spine imaging with a focus on the dens, specifically covering the normal development and ossification of the dens, common congenital variants and their various imaging appearances, fracture classifications, imaging appearances, and treatment options.
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                Author and article information

                Journal
                Clin Med Insights Arthritis Musculoskelet Disord
                Clin Med Insights Arthritis Musculoskelet Disord
                AMD
                spamd
                Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
                SAGE Publications (Sage UK: London, England )
                1179-5441
                1 July 2020
                2020
                : 13
                : 1179544120939069
                Affiliations
                [1 ]New York Chiropractic & Physiotherapy Centre, New York Medical Group, Hong Kong, China
                [2 ]School of Medicine, Lincoln University College, Kota Bharu, Malaysia
                Author notes
                [*]Eric Chun Pu Chu, New York Chiropractic & Physiotherapy Centre, 41/F Langham Place Office Tower, 8 Argyle Street, Mongkok, Hong Kong, China. E-mail: eric@ 123456nymg.com.hk
                Author information
                https://orcid.org/0000-0002-0893-556X
                Article
                10.1177_1179544120939069
                10.1177/1179544120939069
                7331757
                32655279
                3a4c696c-cdca-4ca7-9169-516d5e6fab34
                © The Author(s) 2020

                This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License ( https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages ( https://us.sagepub.com/en-us/nam/open-access-at-sage).

                History
                : 29 May 2020
                : 11 June 2020
                Categories
                Case Report
                Custom metadata
                January-December 2020
                ts1

                Rheumatology
                acetaminophen,atlantoaxial subluxation,chiropractic,estrogenic effects,gynecomastia
                Rheumatology
                acetaminophen, atlantoaxial subluxation, chiropractic, estrogenic effects, gynecomastia

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