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      Emergence of BCR-ABL1 Chronic Myeloid Leukemia in a JAK2-V617F Polycythemia Vera

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          Abstract

          Emergence of a new chronic myeloid neoplasm in the setting of a previous one, or their concomitant appearance seems to be a rare event, but plenty of cases have been reported. We describe the case of a patient with JAK2-V617F polycythemia vera, which looses JAK2 clone and develops overt BCR-ABL1 chronic myeloid leukemia after 6 years. Once treatment with tyrosine kinase inhibitors controls BCR-ABL1 clone, JAK2 clone arises again. In this report, we review the literature and discuss the clonal relationship of this event in light of the new molecular data.

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          Polycythemia vera and essential thrombocythemia: 2017 update on diagnosis, risk-stratification, and management.

          Ayalew Tefferi, Tiziano Barbui (2017)
          Polycythemia Vera (PV) and essential thrombocythemia (ET) are myeloproliferative neoplasms respectively characterized by erythrocytosis and thrombocytosis; other disease features include leukocytosis, splenomegaly, thrombosis, bleeding, microcirculatory symptoms, pruritus, and risk of leukemic or fibrotic transformation.
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            Myelofibrosis evolving during imatinib treatment of a chronic myeloproliferative disease with coexisting BCR-ABL translocation and JAK2V617F mutation.

            Guntram Buesche, Michael Flasshove, Felicitas Henneke … (2007)
            Article 0 comments Cited 21 times – based on 0 reviews     Review now
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              JAK2-V617F mutation in a patient with Philadelphia-chromosome-positive chronic myeloid leukaemia.

              Andreas Reiter, Jens Kruth, Philipp Erben … (2007)
              Article 0 comments Cited 18 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): J Hematol
                Journal ID (iso-abbrev): J Hematol
                Journal ID (publisher-id): Elmer Press
                Title: Journal of Hematology
                Publisher: Elmer Press
                ISSN (Print): 1927-1212
                ISSN (Electronic): 1927-1220
                Publication date (Print): April 2020
                Publication date (Electronic): 23 April 2020
                Volume: 9
                Issue: 1-2
                Pages: 23-29
                Affiliations
                [a ]Catedra de Hematologia, Hospital de Clinicas, Montevideo 11300, Uruguay
                [b ]Departamento Basico de Medicina, Hospital de Clinicas, Montevideo 11300, Uruguay
                Author notes
                [c ]Corresponding Author: Mariana Lorenzo, Hematology Department, Hospital de Clinicas Av Italia SN, Montevideo 11300, Uruguay. Email: marilorenzo44@ 123456gmail.com
                Article
                DOI: 10.14740/jh591
                PMC ID: 7188376
                PubMed ID: 32362982
                SO-VID: 3a058a32-acf7-4452-ba7a-9eb9a7068b21
                Copyright © Copyright 2020, Lorenzo et al.
                License:

                This article is distributed under the terms of the Creative Commons Attribution Non-Commercial 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 26 November 2019
                Date accepted : 27 February 2020
                Categories
                Subject: Case Report

                Keywords: chronic myeloid leukemia,chronic myeloproliferative neoplasm,bcr-abl1,jak2-v617f
                Data availability:
                Keywords: chronic myeloid leukemia, chronic myeloproliferative neoplasm, bcr-abl1, jak2-v617f

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