Salinity is one of the most devastating environmental factors limiting crop productivity worldwide. Therefore, our study investigates the effect of seed priming with zinc oxide nanoparticles (ZnO NPs: 0, 50, and 100 mg L−1), 24-epibrassinolide (EBL: 0.0, 0.2, and 0.4 µM), and their combined treatments on maize (Zea mays L.) grown with different levels of saline stress (i.e., control, 5, 10 dS m−1) under semi-controlled conditions. Higher saline stress (10 dS m−1) negatively influenced the growth traits, physiological attributes, and elemental (i.e., Zn and K) uptake for both roots and shoots of maize, whereas it increased Na+ accumulation and Na+/K+ ratio in comparison to other treatments. However, seed priming with ZnO NPs and EBL as well as their combinations showed amelioration of the detrimental effects of saline stress on the growth and physiological and biochemical performance of maize. In general, seed priming with combined treatments of ZnO NPs and EBL were significantly more effective than either ZnO NPs or EBL as individual treatments. A combination of 100 mg L−1 ZnO NPS + 0.2 µM EBL resulted in the highest values of root length, root surface area, stem diameter, relative leaf water contents, total chlorophyll, net rate of photosynthesis, zinc accumulation, and K+ uptake, while it resulted in the lowest Na+ and Na+/K+ ratio, especially under the highest saline-stress treatment. Thus, we concluded that seed priming with combined ZnO NPs and EBL can effectively mitigate the saline-stress-mediated decline in the morphological, physiological, and biochemical traits of maize.