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      Review of African swine fever: Transmission, spread and control

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          Abstract

          African swine fever is one of the most important and serious diseases of domestic pigs. Its highly contagious nature and ability to spread over long distances make it one of the most feared diseases, since its devastating effects on pig production have been experienced not only in most of sub-Saharan Africa but also in western Europe, the Caribbean, Brazil and, most recently, the Caucasus. Unlike most diseases of livestock, there is no vaccine, and therefore prevention relies entirely upon preventing contact between the virus and the susceptible host. In order to do so it is necessary to understand the way in which the virus is transmitted and spreads. By implementing strict biosecurity measures that place barriers between the source of virus and the pigs it is possible to prevent infection. However, this has implications for free-ranging pig husbandry systems that are widespread in developing countries. Attempts to produce a vaccine are ongoing and new technology offers some hope for the future, but this will not remove the necessity for implementing adequate biosecurity on pig farms.

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          Most cited references31

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          Antigenic and immunogenic properties of a chimera of two immunodominant African swine fever virus proteins.

          A chimera of the two immunodominant African swine fever (ASF) virus proteins p54 and p30 was constructed by insertion of the gene CP204L into a Not I restriction site of E183L gene. The resulting chimeric protein p54/30, expressed by a recombinant baculovirus in insect cells and in Trichoplusia ni larvae, retained antigenic determinants present in both proteins and reacted in Western blot with a collection of sera from inapparent ASF virus carrier pigs. Remarkably, pigs immunized with the chimeric protein developed neutralizing antibodies and survived the challenge with a virulent African swine fever virus, presenting a reduction of about two logs in maximum viremia titers with respect to control pigs. In conclusion, this study revealed that the constructed chimeric protein may have utility as a serological diagnostic reagent and for further immunological studies that may provide new insights on mechanisms of protective immunity to ASFV.
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            African swine fever: a retrospective view.

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              Intra-genotypic resolution of African swine fever viruses from an East African domestic pig cycle: a combined p72-CVR approach

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                Author and article information

                Contributors
                Role: ND
                Role: ND
                Journal
                jsava
                Journal of the South African Veterinary Association
                J. S. Afr. Vet. Assoc.
                AOSIS Publishing (Cape Town )
                2224-9435
                2009
                : 80
                : 2
                : 58-62
                Affiliations
                [1 ] TAD Scientific South Africa
                [2 ] University of Pretoria South Africa
                [3 ] Onderstepoort Veterinary Institute South Africa
                Article
                S1019-91282009000200001
                398cc151-f957-4c09-af82-38223838eb59

                http://creativecommons.org/licenses/by/4.0/

                History
                Product

                SciELO South Africa

                Self URI (journal page): http://www.scielo.org.za/scielo.php?script=sci_serial&pid=1019-9128&lng=en
                Categories
                Agriculture, Dairy & Animal Science
                Veterinary Sciences

                Animal agriculture,General veterinary medicine
                African swine fever,biosecurity,control,prevention,transmission

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