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Cancer related inflammation: The macrophage connection
August 2008
August 2008
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Abstract
Tumor-associated macrophages (TAM) are key regulators of the link between inflammation
and cancer. In the tumor microenvironment neoplastic cells shape the differentiation
and functional orientation of TAM which, in turn, express several protumoral functions,
including secretion of growth factors and matrix-proteases, promotion of angiogenesis
and suppression of adaptive immunity. This review analyzes our current knowledge of
TAM and their involvement in tumor development and progression. The interplay between
TAM and neoplastic cells represents a promising target of future therapeutic approaches.