Depletion of T regulatory cells promotes natural killer cell-mediated cardiac allograft vasculopathy.

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Abstract

A role for natural killer (NK) cells in cardiac allograft vasculopathy (CAV) was suggested by our earlier observation that CAV arises even in the absence of detectable antidonor T-cell or B-cell reactivity in parental to F1 mouse heart grafts. However, prevention of CAV in this setting required the depletion of both NK and CD4 T cells.

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Journal

Journal ID (iso-abbrev): Transplantation

Title: Transplantation

Publisher: Ovid Technologies (Wolters Kluwer Health)

ISSN (Electronic): 1534-6080

ISSN (Print): 0041-1337

Publication date (Electronic): Oct 27 2014

Volume: 98

Issue: 8

Affiliations

[1 ] 1 Transplantation Center and Department of Surgery, Massachusetts General Hospital, Boston, MA. 2 Department of Pathology, Massachusetts General Hospital, Boston, MA. 3 Division of Cardiac Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA. 4 Address correspondence to Joren C. Madsen, M.D., D.Phil., White 510a, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114.

Article

Publisher Item ID: 00007890-201410270-00007 Mid ID: NIHMS609796

DOI: 10.1097/TP.0000000000000329

PMC ID: 4203423

PubMed ID: 25321164

SO-VID: 389b6440-afc2-4b4c-b22a-e0e0d3971876

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